Results 161 to 170 of about 928,578 (204)

The Effect of LRRK2 and GBA1 Mutations on Survival in Early‐ and Late‐Onset Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Mutations in the glucocerebrosidase 1 (GBA1) and leucine‐rich repeat kinase 2 (LRRK2) genes are associated with Parkinson's disease (PD) phenotype. Objective To asses the contribution of genetic status to long‐term survival of patients with PD.
Raz Rubin, Roy N. Alcalay, Nurit Omer, Orly Goldstein, Mali Gana Weisz, Anat Mirelman, Avner Thaler   +6 more
wiley   +1 more source

Lewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank

Movement Disorders, EarlyView.
Abstract Background Lewy body disease (LBD) is defined by neuronal α‐synuclein pathology, but how Braak‐staged LBD relates to mixed neuropathology and clinical manifestations within a single population‐based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which may better inform real ...
Vitor Ribeiro Paes, Felipe Luiz Pereira, Caroline Matos Silva, Filipe Oto Cunha de Moraes, Inês Liguori Padrão, Alberto Fernando Oliveira Justo, Roberta Diehl Rodriguez, Michel Satya Naslavsky, Renata Elaine Paraizo Leite, Carlos Augusto Gonçalves Pasqualucci, Mayana Zatz, Eduardo Ferriolli, Claudia Kimie Suemoto, Lea Tenenholz Grinberg   +13 more
wiley   +1 more source

Association Between Long‐Term Exposure to Air Pollution and Parkinson's Disease: Administrative Cohort of Older Adults in South Korea

Movement Disorders, EarlyView.
Abstract Background Evidence regarding the association between long‐term exposure to ambient air pollution and Parkinson's disease (PD) remains inconsistent, particularly among older adults in Asian populations. Objective We aimed to examine the association between long‐term exposure to ambient air pollutants and incident PD in a nationwide ...
Jongmin Oh, Jisun Myung, Dong‐Wook Lee, Changwoo Han, Yun‐Chul Hong, Soontae Kim, Yoon‐Hee Kang, Hyun‐Joo Bae, Youn‐Hee Lim   +8 more
wiley   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Pathogenic GBA1 Variants and their Interaction with the Gut–Microbiota–Brain Axis in Parkinson's Disease

Movement Disorders, EarlyView.
Helen Dainton‐Howard, Phillip Engen, Kristi Lawrence, Maliha Shaikh, Mohamad Abdel‐Mohsen, Stefan Green, Ankur Naqib, Neha Joshi, Michelle Villanueva, Alana Kirby, Ali Keshavarzian, Christopher Goetz   +11 more
wiley   +1 more source