Results 171 to 180 of about 91,213 (314)

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain.
Bitan, Gal, Di, Jing, Jiang, Lin, Li, Binsen, Murray, Kevin A, Shin, Woo Shik, Sun, Chuanqi   +6 more
core  

C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration [PDF]

Clémence Rose, Rodrigo Hernán Tomas‐Grau, Brenda Zabala, Patrick P. Michel, Jean Michel Brunel, Rosana Chehı́n, Rita Raisman‐Vozari, Laurent Ferrié, Bruno Figadère   +8 more
openalex   +1 more source

A fluorescent probe as a lead compound for a selective α-synuclein PET tracer: development of a library of 2-styrylbenzothiazoles and biological evaluation of [18F]PFSB and [18F]MFSB

, 2023
Adriana Di Nanni, Ran Sing Saw, Umberto Maria Battisti, Gregory Bowden, Bernd J. Pichler, Kristina Herfert, Matthias M. Herth, Andreas Maurer   +7 more
openalex   +2 more sources

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria

Nature Communications
Mitochondrial dysfunction and accumulation of α-synuclein aggregates are hallmarks of the neurodegenerative Parkinson’s disease and may be interconnected.
Tetiana Serdiuk, Yanick Fleischmann, Dhiman Ghosh, Aro Delparente, Viviane Reber, Larissa Frey, David Rhyner, Juan Gerez, Norbert Volkmar, Lucie Kralickova, Guillaume Mas, Christian Dörig, Sebastian Hiller, Roger Schibli, Linjing Mu, Paola Picotti, Roland Riek   +16 more
doaj   +1 more source

Abstract 1146 Insight into Synucleinopathies: Comparative Evaluation of Wild-Type α-, β-, and -Synucleins in a Yeast Model [PDF]

Sebastian Gacek, Leslie Casares, Federica Bertolotti, Isaiah Moonlight, Ryan Osselborn, Marcelo Camba, Shubhik DebBurman   +6 more
openalex   +1 more source

α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease

, 2023
Eduardo Martín-López, D. J. Vidyadhara, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Natalie J. Spence, Bowen Brennan, Kimberly Han, Betül Yücel, Sreeganga S. Chandra, Charles A. Greer   +11 more
openalex   +2 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Structural and Functional Insights into α-Synuclein Fibril Polymorphism [PDF]

, 2021
Surabhi Mehra, Laxmikant Gadhe, Riya Bera, Ajay Singh Sawner, Samir K. Maji   +4 more
openalex   +1 more source