Results 101 to 110 of about 34,912 (203)

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort

Hematology
Background: Hemoglobin (Hb) Hekinan is a prevalent α-globin variant frequently missed in thalassemia screening centers using high-performance liquid chromatography (HPLC) or capillary electrophoresis.
Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert   +5 more
doaj   +1 more source

The prevalence and molecular spectrum of α- and β-globin gene mutations in 14,332 families of Guangdong Province, China.

PLoS ONE, 2014
ObjectiveTo reveal the familial prevalence and molecular variation of α- and β-globin gene mutations in Guangdong Province.MethodsA total of 40,808 blood samples from 14,332 families were obtained and analyzed for both hematological and molecular ...
Aihua Yin, Bing Li, Mingyong Luo, Longchang Xu, Li Wu, Liang Zhang, Yuanzhu Ma, Tingting Chen, Shuang Gao, Juqing Liang, Hao Guo, Danqing Qin, Jicheng Wang, Tenglong Yuan, Yixia Wang, Wei-wei Huang, Wen-Fei He, Yanxia Zhang, Chang Liu, Sujian Xia, Qingshan Chen, Qingguo Zhao, Xiaozhuang Zhang   +22 more
doaj   +1 more source

PBI22 Rethinking the Health-Economic Evaluation Framework for GENE Therapies: The Betibeglogene Autotemcel (BETI-CEL) Case in Î’-Thalassemia [PDF]

Value in Health, 2020
L. Undreiner, M. Caillon, C. Paramore, S. Roze   +3 more
openaire   +1 more source

Knowledge, Attitude, and Perception of Nursing Students in Selected Private Universities on Integration of Genomic Information Into Clinical Assessment and Patient Education: A Descriptive Cross‐Sectional Survey

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims The rapid growth of genomics in healthcare has led to significant advances, and the integration of genetic information into clinical and patient education among nursing students during their training years is crucial to equip them for the genomic era.
Iyanuoluwa Oreofe Ojo, Toluwanimi Anuoluwapo Asumo, Ajibola Omobola Ojo, Prisca Olabisi Adejumo   +3 more
wiley   +1 more source

Molecular and Hematological Characterization of α-Thalassemia in Denizli Province

Acta Haematologica Oncologica Turcica
Aim: Alpha thalassemia, a common monogenic disorder, occurs with defective synthesis of the α-globin chain and has a very wide clinical spectrum depending on the disorders in the globin genes.
Derya Karaer, Tuba Uğurlu Er, Nevin Alayvaz Aslan, Taner Durak   +3 more
doaj   +1 more source

Detection of α-Thalassemia by Using Multiplex Ligation-Dependent Probe Amplification as an Additional Method for Rare Mutations in Southern Turkey [PDF]

, 2015
α-thalassemia is the most common single gene disorder in the Cukurova Region in Turkey. It is therefore routinely screened, including premaritally, in our region.
Acik, Didar Yanardag, Ayaz, Akif, Balci, Tugce B., Canbek, Sezin, Yalcintepe, Sinem, Yilmaz, Basak Taburoglu, Yuregir, Ozge Ozalp   +6 more
core   +2 more sources

The Role of Haemoglobin Variants and Red Blood Cell Polymorphisms in Asymptomatic Malaria: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Human phenotypes, particularly blood group polymorphisms (ABO) and haemoglobin variants (HbAA and HbAS), have been widely studied in relation to clinical malaria. However, their role in asymptomatic malaria remains underexplored. This study therefore, investigated the association of these phenotypic variants with the burden
Enoch Aninagyei, Comfort Addo Boatey, John Gameli Deku, Adjoa Agyemang Boakye, Ebenezer Nyarkotey, Gifty Larbi, Desmond Omane Acheampong   +6 more
wiley   +1 more source

Analysis of genotypic distribution and rare variants of patients with α/β-thalassemia screened in one hospital in Beijing, China

Human Genomics
Objective Thalassemia is among the most common inherited diseases worldwide. We aimed to analyze the genotype and frequency distribution of thalassemia in a general hospital in Beijing and provide a reference for genetic counseling and prenatal diagnosis.
Han Zhang, Ziran Wang, Zhuo Yang, Xinfei Chen, Hongrui Xu, Xianhui Zeng, Qi Yu, Lingjun Kong, Rui Zhang, Jie Yi, Jie Wu, Yong Gan, Yu Chen, Ali Ye, Ziyi Wang, Dong Zhang, Xiao Han, Juan Du, Yaling Dou   +18 more
doaj   +1 more source

Alpha-thalassemia due to novel deletions and complex rearrangements in the subtelomeric region of chromosome 16p [PDF]

, 2017
2º Dia do Jovem Investigador do Instituto Nacional de Saúde Doutor Ricardo Jorge, INSA, 8 maio 2017Introduction: Inherited deletions removing the α-globin genes and/or their upstream regulatory elements (MCSs) give rise to alpha-thalassemia, one of the ...
Batalha Reis, Ana, Coelho, Andreia, F. Lacerda, João, Faustino, Paula, Ferrão, José, Gomes, Susana, Gonçalves, João, Gonçalves, Lúcia, Kjollerstrom, Paula, Lavinha, João, Loureiro, Pedro, Maia, Raquel, Miranda, Armandina, Monteiro, Estela, Pina, Francisca, Seuanes, Filomena, Silva, Marisa, Sonesson, Annika, Valtonen-André, Camila   +18 more
core   +1 more source