Results 111 to 120 of about 34,320 (185)

Archipelago Method for Variant Set Association Test Statistics

Genetic Epidemiology, Volume 50, Issue 1, February 2026.
ABSTRACT Variant set association tests (VSAT), especially those incorporating rare variants via variant collapse, are invaluable in genetic studies. However, unlike Manhattan plots for single‐variant tests, VSAT statistics lack intrinsic genomic coordinates, hindering visual interpretation.
Dylan Lawless, Ali Saadat, Mariam Ait Oumelloul, Luregn J. Schlapbach, Jacques Fellay   +4 more
wiley   +1 more source

Recent Insights Into Circulating Adipokines in Obesity: Systematic Review and Meta‐Analysis

Obesity Science &Practice, Volume 12, Issue 1, February 2026.
ABSTRACT Background Adipokines are dysregulated in obesity and exacerbate proinflammatory conditions. Although several studies have investigated adipokine levels in obesity, their findings have been inconsistent, leaving the precise nature of these alterations uncertain.
Sunita Sunita, Mohammad Ghozali, Mohammad Rizki Akbar, Annisa Dewi Nugrahani, Iis Inayati Rakhmat, Siti Nur Fatimah, Yuni Susanti Pratiwi, Eko Fuji Ariyanto, Gaga Irawan Nugraha, Mas Rizky A. A. Syamsunarno, Tri Hanggono Achmad   +10 more
wiley   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

Iron Metabolism: From Health to Disease [PDF]

, 2014
Background Iron is vital for almost all living organisms by participating in a wide range of metabolic processes. However, iron concentration in body tissues must be tightly regulated since excessive iron may lead to microbial infections or cause tissue
Fernandes, Rúben, Oliveira, Fernando, Rocha, Sara   +2 more
core   +1 more source

Prevalence of Severe Thalassemia and Performance of Prenatal Screening Tests Among Pregnant Women at Siriraj Thalassemia Center in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Severe thalassemia remains a significant public health concern in Southeast Asia. Prenatal screening is an effective strategy for early detection and prevention. This study aimed to determine the prevalence of severe thalassemia and assess the performance of prenatal screening at the Siriraj Thalassemia Center, Siriraj Hospital, Thailand.
Kwandao Malasai, Usa Chaikledkaew, Pattarawalai Talungchit, Sitaporn Youngkong, Wanvisa Udomsinprasert, Chanin Limwongse, Jiraphun Jittikoon   +6 more
wiley   +1 more source

Hemoglobin Subunit-Subunit Affinity-Determinant of Hemoglobin Formation [PDF]

, 1989
Hemoglobin A₂ is often elevated in β-thalassemia and decreased in α-thalassemia. This might be due to hemoglobin subunit-subunit affinity variation. It has been inferred from the study of abnormal hemoglobins that the a subunits have higher affinity for ...
Carter, Inge R., Mansouri, Ali
core   +2 more sources

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source

Analysis of thalassemia genotypes and HbA2 test results in pregnant women in Shenzhen, China

Scientific Reports
To examine the thalassemia genotypes and distribution among pregnant women in Shenzhen, as well as the diagnostic value of HbA2 in thalassemia screening, in order to provide scientific evidence for thalassemia prevention and control in this region.
Hou Qian, Weihua Zhao, Weifeng Li, Yike Wu, Xiuhua Lin, Jianlin Huang, Hong Zhang, Dayong Gu   +7 more
doaj   +1 more source

Study on the diagnostic and differential value of thalassemia through combined blood routine examination and reticulocyte detection

Frontiers in Pediatrics
ObjectiveThis study aims to explore the diagnostic and differential values of thalassemia genotypes using combined complete blood count (CBC) and reticulocyte parameter analysis in neonates, considering physiological age-related hematological changes ...
Haiyan Ke, Haiyan Ke, Hongxia Zhang, Hongxia Zhang, Hong Jiang, Hong Jiang, Sheng Li, Sheng Li, Hui Wang, Hui Wang   +9 more
doaj   +1 more source

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundRecent studies have discovered that α‐globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α ...
Anthony O. Etyang, Christopher Khayeka‐Wandabwa, Sailoki Kapesa, Esther Muthumbi, Emily Odipo, Marylene Wamukoya, Nicholas Ngomi, Tilahun Haregu, Catherine Kyobutungi, Metrine Tendwa, Johnstone Makale, Alex Macharia, J. Kennedy Cruickshank, Liam Smeeth, J. Anthony G. Scott, Thomas N. Williams   +15 more
doaj   +1 more source