Results 51 to 60 of about 3,403,836 (312)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds

open access: yesDrug Design, Development and Therapy, 2019
Abdulsalam AM Alkhaldi,1 Harry P de Koning,2 Syed Nasir Abbas Bukhari31Biology Department, College of Science, Jouf University, Sakaka, Aljouf 2014, Saudi Arabia; 2Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life ...
Alkhaldi AAM, de Koning HP, Bukhari SNA
doaj  

The concept of the Sun as ἡγεμονικόν in the Stoa and in Manilius’Astronomica

open access: yesRevista Archai, 2017
Hegemonikon in Stoic vocabulary is the technical term for the chief part or command-centre’of the soul. As we know, the Stoics considered the cosmos a living organism, and they theorised both about the human soul’s Hegemonikon and about its counterpart in the World-soul.
openaire   +3 more sources

On (μ1, μ2, μ3)-Weakly Generalized Closed Sets

open access: yesEuropean Journal of Pure and Applied Mathematics, 2020
This paper defines a new generalization of closed sets in a tri-generalized topological space called (μ1, μ2, μ3)-weakly generalized closed set (or briefly (μ1,μ2, μ3)-wg closed set) which is defined as follows: A subset A of X is (μ1, μ2, μ3)-weakly generalized closed set if clμ1(intμ2(A)) ⊆U whenever A ⊆ U and U is μ3-open in X.
Breix Michael Agua, Rolando N. Paluga
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The changes of α-galactosides during germination and high pressure treatment of chick-pea seeds

open access: yesCzech Journal of Food Sciences, 2004
The α-galactosides negatively affect of digestibility of grain legumes. The most effective way of α-galactosides decreasing is germination. The content of α-galactosides in chick-pea was decreased by 4 days germination up to 24% of original value in dry ...
J. Dostálová   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Antioxidation capacity of Maillard systems with carbonyl products of sugar fragmentation

open access: yesCzech Journal of Food Sciences, 2004
A role of reactive C2-C5 α-dicarbonyl and α-hydroxycarbonyl products of sugar fragmentation in the development of antioxidative activity (AOA) was investigated after heating in 0.5M binary aqueous mixtures with amino acids.
K. Cejpek, L. Jarolímová, J. Velíšek
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Κριτική - Έτος Α' τευχ. 1-12 (15 Ιουνίου 1923 - 30 Μαΐου 1924)

open access: yes, 1923
Στο Έτος Α’ περιλαμβάνονται 12 ...

core  

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