Results 51 to 60 of about 3,503,326 (315)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds

open access: yesDrug Design, Development and Therapy, 2019
Abdulsalam AM Alkhaldi,1 Harry P de Koning,2 Syed Nasir Abbas Bukhari31Biology Department, College of Science, Jouf University, Sakaka, Aljouf 2014, Saudi Arabia; 2Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life ...
Alkhaldi AAM, de Koning HP, Bukhari SNA
doaj  

The changes of α-galactosides during germination and high pressure treatment of chick-pea seeds

open access: yesCzech Journal of Food Sciences, 2004
The α-galactosides negatively affect of digestibility of grain legumes. The most effective way of α-galactosides decreasing is germination. The content of α-galactosides in chick-pea was decreased by 4 days germination up to 24% of original value in dry ...
J. Dostálová   +5 more
doaj   +1 more source

The concept of the Sun as ἡγεμονικόν in the Stoa and in Manilius’Astronomica

open access: yesRevista Archai, 2017
Hegemonikon in Stoic vocabulary is the technical term for the chief part or command-centre’of the soul. As we know, the Stoics considered the cosmos a living organism, and they theorised both about the human soul’s Hegemonikon and about its counterpart in the World-soul.
openaire   +3 more sources

On (μ1, μ2, μ3)-Weakly Generalized Closed Sets

open access: yesEuropean Journal of Pure and Applied Mathematics, 2020
This paper defines a new generalization of closed sets in a tri-generalized topological space called (μ1, μ2, μ3)-weakly generalized closed set (or briefly (μ1,μ2, μ3)-wg closed set) which is defined as follows: A subset A of X is (μ1, μ2, μ3)-weakly generalized closed set if clμ1(intμ2(A)) ⊆U whenever A ⊆ U and U is μ3-open in X.
Breix Michael Agua, Rolando N. Paluga
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Antioxidation capacity of Maillard systems with carbonyl products of sugar fragmentation

open access: yesCzech Journal of Food Sciences, 2004
A role of reactive C2-C5 α-dicarbonyl and α-hydroxycarbonyl products of sugar fragmentation in the development of antioxidative activity (AOA) was investigated after heating in 0.5M binary aqueous mixtures with amino acids.
K. Cejpek, L. Jarolímová, J. Velíšek
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Κριτική - Έτος Α' τευχ. 1-12 (15 Ιουνίου 1923 - 30 Μαΐου 1924)

open access: yes, 1923
Στο Έτος Α’ περιλαμβάνονται 12 ...

core  

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