Results 71 to 80 of about 3,503,326 (315)

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine.

open access: yes, 2020
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal muscle paralysis.
Nirthanan, S, Selvanayagam Nirthanan
core   +1 more source

Synthesis of γ-Nitro Aliphatic Methyl Esters Via Michael Additions Promoted by Microwave Irradiation

open access: yesMolecules, 2009
A simple and efficient protocol has been developed for the direct synthesis of γ-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally,
Francisco D. Díaz-Coutiño   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Μηνιαία έκδοση

open access: yes, 1923
Το έτος Α' περιλαμβάνει 12 ...

core  

Observation of the ψð3686ß decays into Σ+ Σ - ω and Σ+ Σ - φ

open access: yes, 2023
Based on (2712.4 +/- 14.3) x 106 events recorded at the psi(3686) nominal mass collected with the BESIII detector operating at the BEPCII collider, the psi(3686) -> E +/- E over bar -omega and E +/- E over bar -phi decays are observed for the first time with statistical significances of 13.8 sigma and 7.6 sigma, respectively.
Ablikim, M.   +7 more
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

α-N-ядро в би-кооперативных играх [PDF]

open access: yes, 2021
Данная работа посвящена изучению би-кооперативных игр и их решений. В обычных кооперативных играх игрок имеет две опции: присоединиться к коалиции или нет.
Черников Евгений Викторович   +1 more
core  

The effect of lycopene and vitamin E on the growth performance, quality and oxidative stability of chicken leg meat

open access: yesCzech Journal of Animal Science, 2011
A 2 × 3 factorial design experiment was conducted to evaluate the effect of adding lycopene (0 and 75 mg/kg) and vitamin E (0.50 and 100 mg/kg) to the diet of chickens.
M. Englmaierová   +3 more
doaj   +1 more source

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