Thiol-reactive analogues of galanthamine, codeine and morphine as potential probes to interrogate allosteric binding within nAChRs [PDF]
, 2016 Alkaloids including galanthamine (1) and codeine (2) are reported to be positive allosteric modulators of nicotinic acetylcholine receptors (nAChRs) but the binding sites responsible for this activity are not known with certainty.
Balle, Thomas +3 more
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Neural Plasticity, 2015 Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial ...
Lorenzo Di Cesare Mannelli +4 more
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Possible neuroimmunomodulation therapy in T-cell-mediated oral diseases
Dental Hypotheses, 2015 Introduction: Recurrent aphthous stomatitis and oral lichen planus are local chronic inflammatory diseases which are implicated in T cell-mediated immunity.
Tsuyoshi Sato +4 more
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Sustained increase of alpha7 nicotinic receptors and choline-induced improvement of learning deficit in STOP knock-out mice. [PDF]
, 2007 International audienceMice deficient in the microtubule stabilizing protein STOP (stable tubule only polypeptide) show synaptic plasticity anomalies in hippocampus, dopamine hyper-reactivity in the limbic system and severe behavioral deficits.
Andrieux, Annie +7 more
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Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding [PDF]
, 2018 Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking.
Bloem B +6 more
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Sulfonium Ligands of the α7 nAChR. [PDF]
Molecules, 2021 Horenstein NA, Stokes C, Papke RL.
europepmc +1 more source
Regulation of nicotinic acetylcholine receptors by tyrosine kinases in the peripheral and central nervous system: same players, different roles [PDF]
, 2018 .: Nicotinic acetylcholine receptors (nAChRs) exist in many subtypes and are found in the peripheral and central nervous system where they mediate or modulate synaptic transmission.
Fuhrer, C., Wiesner, A.
core
The Effects of Positive Allosteric Modulators of α7-nAChR on Social Play Behavior in Adolescent Rats Prenatally Exposed to Valproic Acid. [PDF]
Pharmaceuticals (Basel), 2022 Gzielo K, Nikiforuk A.
europepmc +1 more source
Correction to "Development of 11C-Labeled ASEM Analogues for Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR)". [PDF]
ACS Chem Neurosci, 2022 Nag S +12 more
europepmc +1 more source
The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein
Frontiers in Cellular and Infection MicrobiologyThe rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien +6 more
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