Results 91 to 100 of about 18,354 (167)

Proteomic Investigation of Murine Neuronal α7-Nicotinic Acetylcholine Receptor Interacting Proteins [PDF]

, 2018
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel that is expressed widely in vertebrates and is the principal high-affinity α-bungarotoxin (α-bgtx) binding protein in the mammalian CNS.
Mulcahy, Matthew J., Edward Hawrot, Hawrot, Edward, Joao A. Paulo (397190), Matthew J. Mulcahy, Edward Hawrot (781725), Matthew J. Mulcahy (781722), Paulo, Joao A., Joao A. Paulo   +8 more
core   +1 more source

Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury

, 2017
Vagal circuits-α7 nAChR (α7 nicotinic acetylcholine receptor, coded by Chrna7) signaling utilizes spleen as a hub to dampen systemic inflammatory responses. Vagal innervations also extend to the distal airways and alveoli.
Ling Li, Caiqi Zhao, Xiao Su, Yuanyuan Huang, Emily M Su, Michael A Matthay, Xi Yang   +6 more
core   +1 more source

Possible neuroimmunomodulation therapy in T-cell-mediated oral diseases

Dental Hypotheses, 2015
Introduction: Recurrent aphthous stomatitis and oral lichen planus are local chronic inflammatory diseases which are implicated in T cell-mediated immunity.
Tsuyoshi Sato, Michihiko Usui, Yuichiro Enoki, Shoichiro Kokabu, Tetsuya Yoda   +4 more
doaj   +1 more source

Connection of α7 nAChR and VDAC studied by sandwich assays.

, 2013
The schemes (A, C) and results of direct (B, n = 3) and reverse (D, n = 3) sandwich assays demonstrating the connection of α7 nAChR and VDAC in the outer membranes (OM) of the wild-type (WT) mitochondria. Anti-TOM22 – antibody against mitochondrial outer
Maryna Skok (332686), Victor Tsetlin (226325), Elena Kryukova (332684), Olena Lykhmus (332680), Olena Kalashnyk (332681), Volodymyr Chernyshov (332683), Galyna Gergalova (332679), Lyudmyla Koval (332682), Sergiy Komisarenko (332685)   +8 more
core   +1 more source

α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

Neural Plasticity, 2015
Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial ...
Lorenzo Di Cesare Mannelli, Barbara Tenci, Matteo Zanardelli, Paola Failli, Carla Ghelardini   +4 more
doaj   +1 more source

Model showing role of presynaptic α7*nAChR mediated calcium signaling in sustained facilitation of synaptic transmission.

, 2013
Step 1, Activation of presynaptic nAChRs by nicotine induces calcium influx into the presynaptic terminals. Activation of non-α7*nAChR (low Ca2+-permeability) elicits small, acute increases in intracellular Ca2+ at presynaptic terminals.
David A. Talmage (46256), Lorna W. Role (46255), Chongbo Zhong (493668)   +2 more
core   +1 more source

Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR

, 2017
Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a key pathophysiological component of airway remodeling in chronic obstructive pulmonary disease (COPD) for which pharmacotherapy is limited, and only slight ...
Yumin Zhou, Chunxiao Liang, Erkang Yi, Wei Hong, Huanhuan Peng, Lingmei Huang, Binwei Hao, Xiuqin Ye, Zhuxiang Zhao, Mengning Zheng, Pixin Ran, Bing Li, Baoling Liao, Fang Peng, Gongyong Peng, Jinding Pu   +15 more
core   +2 more sources

The Effects of Positive Allosteric Modulators of α7-nAChR on Social Play Behavior in Adolescent Rats Prenatally Exposed to Valproic Acid. [PDF]

Pharmaceuticals (Basel), 2022
Gzielo K, Nikiforuk A.
europepmc   +1 more source

Correction to "Development of ¹¹C-Labeled ASEM Analogues for Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR)". [PDF]

ACS Chem Neurosci, 2022
Nag S, Miranda-Azpiazu P, Jia Z, Datta P, Arakawa R, Moein M, Yang Z, Tu Y, Lemoine L, Ågren H, Nordberg A, Långström B, Halldin C.   +12 more
europepmc   +1 more source

The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein

Frontiers in Cellular and Infection Microbiology
The rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien, Shelly Thao, Lahra Weber, Helen L. Danielson, Agatha D. Boldt, Karsten Hueffer, Maegan M. Weltzin   +6 more
doaj   +1 more source