Results 71 to 80 of about 6,634 (135)

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria.

PLoS ONE, 2012
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release in the brain.
Galyna Gergalova, Olena Lykhmus, Olena Kalashnyk, Lyudmyla Koval, Volodymyr Chernyshov, Elena Kryukova, Victor Tsetlin, Sergiy Komisarenko, Maryna Skok   +8 more
doaj   +1 more source

Extracellular binding of indinavir to matrix metalloproteinase-2 and the alpha-7-nicotinic acetylcholine receptor: implications for use in cancer treatment

Heliyon, 2019
Introduction: Results from recent studies have suggested a role for protease inhibitors in altering mechanisms involved in the initiation and proliferation of cancer cells.
Anna Lee, Erin Saito, Sean Ekins, Aaron McMurtray   +3 more
doaj   +1 more source

Possible neuroimmunomodulation therapy in T-cell-mediated oral diseases

Dental Hypotheses, 2015
Introduction: Recurrent aphthous stomatitis and oral lichen planus are local chronic inflammatory diseases which are implicated in T cell-mediated immunity.
Tsuyoshi Sato, Michihiko Usui, Yuichiro Enoki, Shoichiro Kokabu, Tetsuya Yoda   +4 more
doaj   +1 more source

α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

Neural Plasticity, 2015
Neuropathies are characterized by a complex response of the central nervous system to injuries. Glial cells are recruited to maintain neuronal homeostasis but dysregulated activation leads to pain signaling amplification and reduces the glial ...
Lorenzo Di Cesare Mannelli, Barbara Tenci, Matteo Zanardelli, Paola Failli, Carla Ghelardini   +4 more
doaj   +1 more source

Sulfonium Ligands of the α7 nAChR. [PDF]

Molecules, 2021
Horenstein NA, Stokes C, Papke RL.
europepmc   +1 more source

The Effects of Positive Allosteric Modulators of α7-nAChR on Social Play Behavior in Adolescent Rats Prenatally Exposed to Valproic Acid. [PDF]

Pharmaceuticals (Basel), 2022
Gzielo K, Nikiforuk A.
europepmc   +1 more source

Correction to "Development of ¹¹C-Labeled ASEM Analogues for Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR)". [PDF]

ACS Chem Neurosci, 2022
Nag S, Miranda-Azpiazu P, Jia Z, Datta P, Arakawa R, Moein M, Yang Z, Tu Y, Lemoine L, Ågren H, Nordberg A, Långström B, Halldin C.   +12 more
europepmc   +1 more source

An α7 nAChR approach for the baseline-dependent modulation of deviance detection in schizophrenia: A pilot study assessing the combined effect of CDP-choline and galantamine. [PDF]

J Psychopharmacol, 2023
Choueiry J, Blais CM, Shah D, Smith D, Fisher D, Labelle A, Knott V.   +6 more
europepmc   +1 more source

The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein

Frontiers in Cellular and Infection Microbiology
The rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien, Shelly Thao, Lahra Weber, Helen L. Danielson, Agatha D. Boldt, Karsten Hueffer, Maegan M. Weltzin   +6 more
doaj   +1 more source