Results 81 to 90 of about 18,354 (167)

Compound activity of PMP-311 and PMP-072 on α7 nAChR.

, 2015
A, Competitive binding assay showed that PMP-311 and PMP-072 displaced the α7 nAChR-specific agonist α-bungarotoxin from binding to PC12 cells. B, PMP-311 showed a dose-dependent activation of α7 nAChR with a maximum about 85% that of ACh C, PMP-072 does
Gregory J. LaRosa (685996), Jessica Koepke (685991), Daniel Elbaum (685995), Paul P. Tak (23064), Frieda A. Koopman (613157), Roger Clark (685993), Margriet J. Vervoordeldonk (613162), Diana Lamppu (685994), Marjolein A. van Maanen (685989), Lisette Bevaart (685992), Roger L. Papke (685990)   +10 more
core   +1 more source

AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain

Scientific Reports
Precise control of the α7 nicotinic acetylcholine receptor (α7-nAChR) in specific brain cell types is crucial for understanding its role in neural circuit function and disease.
Giulia Puliatti, Pietro Renna, Martina Battistoni, Roberto Piacentini, Cristian Ripoli, Claudio Grassi   +5 more
doaj   +1 more source

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Marine Drugs, 2015
6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov, Irina V. Shelukhina, Denis S. Kudryavtsev, Tatyana N. Makarieva, Ekaterina N. Spirova, Alla G. Guzii, Valentin A. Stonik, Victor I. Tsetlin   +7 more
doaj   +1 more source

Differential Modulation of GABAA and NMDA Receptors by an α7-nicotinic Acetylcholine Receptor Agonist in Chronic Glaucoma

Frontiers in Molecular Neuroscience, 2017
Presynaptic modulation of γ-aminobutyric acid (GABA) release by an alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist promotes retinal ganglion cell (RGC) survival and function, as suggested by a previous study on a chronic glaucomatous model ...
Xujiao Zhou, Xujiao Zhou, Xujiao Zhou, Yuan Zong, Yuan Zong, Yuan Zong, Rong Zhang, Xuejin Zhang, Shenghai Zhang, Jihong Wu, Jihong Wu, Jihong Wu, Jihong Wu, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun   +16 more
doaj   +1 more source

α7-Containing and Non-α7-Containing Nicotinic Receptors Respond Differently to Spillover of Acetylcholine

, 2011
We explored whether nicotinic acetylcholine receptors (nAChRs) might participate in paracrine transmission by asking if they respond to spillover of ACh at a model synapse in the chick ciliary ganglion, where ACh activates diffusely distributed α7- and ...
Doychin Stanchev, Peter B. Sargent
core   +1 more source

Extracellular binding of indinavir to matrix metalloproteinase-2 and the alpha-7-nicotinic acetylcholine receptor: implications for use in cancer treatment

Heliyon, 2019
Introduction: Results from recent studies have suggested a role for protease inhibitors in altering mechanisms involved in the initiation and proliferation of cancer cells.
Anna Lee, Erin Saito, Sean Ekins, Aaron McMurtray   +3 more
doaj   +1 more source

List of the SNPs of the human α7 nAChR in this study.

, 2015
List of the SNPs of the human α7 nAChR in this study.
Fenqin Xue (792144), Ronald J. Lukas (781724), Xiaojun Xu (153741), Yao Huang (216100), Qinhui Zhang (763125), Yongchang Chang (216099), Jianliang Zhang (448868), Yingjie Du (792143), Cong Guo (412764)   +8 more
core   +1 more source

Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria.

PLoS ONE, 2012
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release in the brain.
Galyna Gergalova, Olena Lykhmus, Olena Kalashnyk, Lyudmyla Koval, Volodymyr Chernyshov, Elena Kryukova, Victor Tsetlin, Sergiy Komisarenko, Maryna Skok   +8 more
doaj   +1 more source

Chemical structure of α7 nAChR orthosteric and allosteric ligands examined in the present study.

, 2013
Chemical structure of α7 nAChR orthosteric and allosteric ligands examined in the present study.
Anna Chatzidaki (286476), JasKiran K. Gill (286472), Daniel Ursu (286479), Neil S. Millar (246746), Emanuele Sher (286485)   +4 more
core   +1 more source

Representative western blots of α7-nAChR protein levels in control (C) and peptide (T14, T30) treated GH4-hα7 cells.

, 2013
All experiments were performed a minimum of 2 times. A. Protein levels as assessed in total cell homogenate and in membrane compartments after 6 or 24 hr peptide exposure.
Martina Zimmermann (112724), Susan A. Greenfield (373842), Cherie E. Bond (373841)   +2 more
core   +1 more source