Results 11 to 20 of about 10,488 (180)

The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice

Biomedicines, 2023
Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim   +10 more
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Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596 [PDF]

, 2017
This is the final version of the article. Available from Frontiers Media via the DOI in this record.Alpha7 nicotinic acetylcholine receptors (α7 nAChR) are widely distributed throughout the central nervous system and are found at particularly high levels
Brown, JT, Dunlop, J, Randall, AD, Sitzia, F   +3 more
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Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Journal of Neuroinflammation, 2017
Background α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and are reported to have neuroprotective properties.
Hiral Patel, Jessica McIntire, Sarah Ryan, Anthone Dunah, Ralph Loring   +4 more
doaj   +1 more source

Characterisation of nicotine receptors on human peripheral blood mononuclear cells (PBMC) [PDF]

, 2009
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s00011-008-8171-xAim and objective: The aim of the work was to characterise the nAChRs on human PBMC.
Parsons, M., Whelan, C.J., Wongsriraksa, A.   +2 more
core   +1 more source

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Molecules, 2021
We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice.
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. López   +4 more
doaj   +1 more source

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

Biomolecules, 2020
Objective: Type 2 diabetes (T2D) occurs by deterioration in pancreatic β-cell function and/or progressive loss of pancreatic β-cell mass under the context of insulin resistance.
Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche   +12 more
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Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo

Frontiers in Cell and Developmental Biology, 2023
α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells.
O. V. Shlepova, O. V. Shlepova, M. A. Shulepko, V. O. Shipunova, V. O. Shipunova, M. L. Bychkov, I. D. Kukushkin, I. D. Kukushkin, I. A. Chulina, V. N. Azev, E. I. Shramova, V. A. Kazakov, A. M. Ismailova, Y. A. Palikova, V. A. Palikov, E. A. Kalabina, E. A. Shaykhutdinova, G. A. Slashcheva, E. A. Tukhovskaya, I. A. Dyachenko, A. N. Murashev, S. M. Deyev, S. M. Deyev, S. M. Deyev, M. P. Kirpichnikov, M. P. Kirpichnikov, Z. O. Shenkarev, Z. O. Shenkarev, Z. O. Shenkarev, E. N. Lyukmanova, E. N. Lyukmanova, E. N. Lyukmanova   +31 more
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Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Background: Enriched environment (EE) is a simple and effective intervention to improve cognitive function in post-stroke cognitive impairment (PSCI), partly due to the rebalancing of the cholinergic signaling pathway in the hippocampus.
Mei YUAN, Xin-Xin ZHANG, Xiao-Cui FU, Xia BI   +3 more
doaj   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2011
The  tryptophan  metabolite,  kynurenic  acid (KYNA),  is  classically  known  to  be  an antagonist  of ionotropic glutamate receptors.
Andrew L. Varnell, Donald C. Cooper, Kevin J. Staley, Peter Dobelis   +3 more
core   +3 more sources

A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

FEBS Open Bio, 2017
Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) in microglia attenuates neuroinflammation and regulates TNF‐α release. We used lipopolysaccharide to model inflammation in the microglial cell line EOC20 and examined signaling ...
Justin R. King, Trudy C. Gillevet, Nadine Kabbani   +2 more
doaj   +1 more source