Results 21 to 30 of about 10,488 (180)

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials

Acta Pharmaceutica Sinica B, 2017
The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion channel implicated in cognition and neuropsychiatric disorders.
Taoyi Yang, Ting Xiao, Qi Sun, Kewei Wang   +3 more
doaj   +1 more source

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells [PDF]

, 2018
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Grau, Veronika, Koch, Christian, Magel, Ilona, McIntosh, J. Michael, Padberg, Winfried, Perniss, Alexander, Richter, Katrin, Sander, Michael, Schweda, Elke K. H., Wichmann, Sven, Wilker, Sigrid, Wolf, Philipp M.   +11 more
core   +1 more source

α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

JCI Insight, 2021
Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH).
Alexander Vang, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R. Morrison, Thomas J. Mancini, Richard T. Clements, Iuliia Polina, Michael W. Cypress, Bong Sook Jhun, Edward Hawrot, Ulrike Mende, Jin O-Uchi, Gaurav Choudhary   +13 more
doaj   +1 more source

Nicotine Regulates LPS-Induced Inflammatory Responses in HMC3 Microglia and Exerts Neuronal Protection. [PDF]

Mediators Inflamm
Microglia‐mediated neuroimmune responses have been implicated in central nervous system injury and disease pathogenesis. The α7 nicotinic acetylcholine receptor (α7 nAChR), which is expressed on microglia and participates in microenvironment interactions, is a key mediator of the cholinergic anti‐inflammatory pathway.
Qin Y, Yan X, Luo Y, Wang H, Tian Y, Wu X, Chen H, Hou H, Hu Q.   +8 more
europepmc   +2 more sources

The distribution of charged amino acid residues and the Ca(2+) permeability of nicotinic acetylcholine receptors: a predictive model [PDF]

, 2017
Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca(2+) permeability depending on their subunit composition.
Fucile, Sergio
core   +1 more source

Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Cellular Physiology and Biochemistry, 2014
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia.
Yongliang Jiang, Aiguo Dai, Yumin Zhou, Gongyong Peng, Guoping Hu, Bing Li, James S.K. Sham, Pixin Ran   +7 more
doaj   +1 more source

Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells [PDF]

, 2016
In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Alkahtan, Reem M., Grider, John R., Lyall, Vijay, Mahavadi, Sunila, Mummalaneni, Shobha K., Murthy, Karnam S., Qian, Jie   +6 more
core   +3 more sources

Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits the migration of A549 lung adenocarcinoma cells via regulating alpha 7 nicotinic acetylcholine receptors in vitro

Virology Journal, 2017
Background The aim of this study were to investigate the possible pro-apoptotic mechanisms of the recombinant Newcastle disease virus (NDV) strain rL-RVG, which expresses the rabies virus glycoprotein, in A549 lung adenocarcinoma cells via the regulation
Yulan Yan, Chunxiang Su, Min Hang, Hua Huang, Yinghai Zhao, Xiaomei Shao, Xuefeng Bu   +6 more
doaj   +1 more source

Targeting α7 nicotinic acetylcholine receptors for chronic pain

Frontiers in Molecular Neuroscience, 2022
Despite rapid advances in the field of chronic pain, it remains extremely challenging in the clinic. Pain treatment strategies have not improved for decades as opioids remain the main prescribed drugs for chronic pain management.
Ya-Qun Zhou, Dai-Qiang Liu, Cheng Liu, Ai-Jun Xu, Yu-Ke Tian, Wei Mei, Xue-Bi Tian   +6 more
doaj   +1 more source