Results 91 to 100 of about 9,490 (159)

Ectopic αIIbβ3 Integrin Signaling Involves 12-Lipoxygenaseand PKC-mediated Serine Phosphorylation Events in Melanoma Cells

, 2001
SummaryMegakaryocytic genes such as αIIbβ3 can be expressed by malignant cells as part of the disturbances in their gene regulation. However, the function of the gene product greatly depends on the interaction of the ectopic protein with the new ...
Sándor Paku, József Tóvári, Mohit Trikha, Erzsébet Rásó, Krisztina Tóth, Kenneth Honn, József Tímár   +6 more
core   +1 more source

Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs [PDF]

, 2011
Activated blood platelets mediate the primary response to vascular injury. Although molecular abnormalities of platelet proteins occur infrequently, taken collectively, an inherited platelet defect accounts for a bleeding diathesis in ≈1:20,000 ...
Fang, Juan, Troy B. Hawkins, Sevasti B. Koukouritaki, Eric S. Jensen, Lily M. Du, Wilcox, David A., Mary K. Boudreaux, Kenneth Cornetta, Jensen, Eric S., Boudreauxe, Mary K., Koukouritaki, Sevasti B., Cornetta, Kenneth, Du, Lily M., Hawkins, Troy B., Juan Fang, David A. Wilcox   +15 more
core   +1 more source

CD63 Associates with the αIIbβ3 Integrin-CD9 Complex on the Surface of Activated Platelets

, 2001
SummaryThe tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and have been identified in multi-molecular complexes with specific integrins.
Archibald McNicol, Sara Israels, Catherine Robertson, Eileen McMillan-Ward, Jeffrey Easton   +4 more
core   +1 more source

The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.

PLoS ONE, 2013
Integrin-linked kinase (ILK) is an important signaling regulator that assembles into the heteroternary complex with adaptor proteins PINCH and parvin (termed the IPP complex).
Shigenori Honda, Hiroko Shirotani-Ikejima, Seiji Tadokoro, Yoshiaki Tomiyama, Toshiyuki Miyata   +4 more
doaj   +1 more source

Full-Length αIIbβ3 Cryo-EM Structure Reveals Intact Integrin Initiate-Activation Intrinsic Architecture [PDF]

Integrin αIIbβ3 is the key receptor regulating platelet retraction and accumulation and a proven drug-target for antithrombotic therapies. Here we resolve the cryoEM structures of the full-length αIIbβ3, which covers three distinct states along the ...
Wu, Hongjiang, Dalton, Valerie, Huo, Tong, Wang, Zhao, Sen, Mehmet, Moussa, Zeinab   +5 more
core   +1 more source

A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin αIIbβ3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction [PDF]

, 2018
We identified a novel heterozygous ITGB3 p.T720del mutation in a pedigree with macrothrombocytopenia exhibiting aggregation dysfunction. Platelet aggregation induced by ADP and collagen was significantly reduced, while ristocetin aggregation was normal ...
Nakagawa, Masao, Goto, Hideki, Masao Nakagawa, Teshima, Takanori, Onozawa, Masahiro, Kunishima, Shinji, Shinji Kunishima, Hashimoto, Daigo, Kahata, Kaoru, Kohei Okada, Hayasaka, Koji, Migita, Ohsuke, Daigo Hashimoto, Hata, Kenichiro, Koji Hayasaka, Takahiro Yamada, Kenichiro Hata, Yamada, Takahiro, Ohsuke Migita, Hideki Goto, Naohiro Miyashita, Takeshi Kondo, Miyashita, Naohiro, Kaoru Kahata, Okada, Kohei, Kondo, Takeshi, Masahiro Onozawa, Takanori Teshima   +27 more
core   +1 more source

Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model

Nature Communications
Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet αIIbβ3 in VT is
Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout   +14 more
doaj   +1 more source

Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation

Scientific Reports, 2017
Under ischemic conditions, tissues are exposed to hypoxia. Although human physiology, to a certain extent, can adapt to hypoxic conditions, the impact of low oxygen levels on platelet function is unresolved.
Klytaimnistra Kiouptsi, Stepan Gambaryan, Elena Walter, Ulrich Walter, Kerstin Jurk, Christoph Reinhardt   +5 more
doaj   +1 more source

A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
This study explored the possible bioactive ingredients and target protein of Rostellularia procumbens (L.) Nees. The results of optical turbidimetry revealed that the ethyl acetate extraction obtained from R.
Songtao Wu, Yanfang Yang, Bo Liu, Zhoutao Xie, Weichen Xiong, Pengfei Hao, Wenping Xiao, Yuan Sun, Zhongzhu Ai, Hezhen Wu   +9 more
doaj   +1 more source

Structure and Function of Murine αIIbβ3 (GPIIb/IIIa): Studies Using Monoclonal Antibodies and β3-null Mice

, 2000
SummaryThe αIIbβ3 receptor (GPIIb/IIIa) is the only platelet-specific integrin receptor and the most abundant adhesion/aggregation receptor on the surface of human platelets.
Barry Coller, Susan Smyth, Dimitrios Tsakiris, Lesley Scudder   +3 more
core   +1 more source