Results 71 to 80 of about 9,490 (159)

Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function

Research and Practice in Thrombosis and Haemostasis
Background: Previous studies have shown that thiol isomerases such as ERp46 positively regulate platelet function by reducing integrin αIIbβ3 disulfides, and the transmembrane thiol isomerase TMX1 negatively regulates integrin αIIbβ3 activation. However,
Zhenzhen Zhao, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang, Yi Wu   +7 more
doaj   +1 more source

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Nature Communications, 2018
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation ...
Xiaohong Ruby Xu, Yiming Wang, Reheman Adili, Lining Ju, Christopher M. Spring, Joseph Wuxun Jin, Hong Yang, Miguel A. D. Neves, Pingguo Chen, Yan Yang, Xi Lei, Yunfeng Chen, Reid C. Gallant, Miao Xu, Hailong Zhang, Jina Song, Peifeng Ke, Dan Zhang, Naadiya Carrim, Si-Yang Yu, Guangheng Zhu, Yi-Min She, Terry Cyr, Wenbin Fu, Guoqing Liu, Philip W. Connelly, Margaret L. Rand, Khosrow Adeli, John Freedman, Jeffrey E. Lee, Patrick Tso, Patrizia Marchese, W. Sean Davidson, Shaun P. Jackson, Cheng Zhu, Zaverio M. Ruggeri, Heyu Ni   +36 more
doaj   +1 more source

αIIbβ3 and Its Antagonism at the New Millennium

, 2001
SummaryBecause of its major role in regulating platelet functions and its prominence on the cell surface, integrin αIIbβ3 has been the subject of intensive investigations.
Edward Plow, Tatiana Byzova, Thomas Haas, Zihui Xiao, Czeslaw Cierniewski   +4 more
core   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

An αIIbβ3 ligand-mimetic murine monoclonal antibody that produces platelet activation by engaging the FcγIIa receptor

Blood Advances
: To produce a murine monoclonal antibody (mAb) that binds to glycoprotein IIb/IIIa (αIIbβ3) and inhibits clot retraction (CR), we immunized mice with human platelets and tested hybridoma supernatants for their ability to bind to αIIbβ3 and inhibit CR ...
Jialing Wang, Lorena Buitrago, Lu Wang, Jihong Li, Thomas Walz, Barry S. Coller   +5 more
doaj   +1 more source

αIIbβ3-deficient platelets fail to spread, form thrombi, or efficiently secrete granule contents over immobilized IgG.

, 2015
(A) Washed platelets from αIIbβ3-/- or αIIbβ3+/+ FcγRIIapos mice were allowed to spread and analyzed as described in the legend for Fig 1. Representative images of three independent experiments are shown. Scale bar, 5 μm.
Jing Dai (470985), Cunji Gao (785417), Jieqing Zhu (785416), Peter J. Newman (706854), Junling Liu (127905), Debra K. Newman (706856), Huiying Zhi (706852)   +6 more
core   +1 more source

Targeting CD148 for Antithrombotic Therapy: Functional and Molecular Evaluation of AKB‐9778

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT CD148 is the primary receptor‐type protein tyrosine phosphatase (PTP) regulating platelet activation, and its inhibition has been proposed as a novel anti‐thrombotic strategy with potentially lower bleeding risk than current therapies. However, selective and potent inhibitors of CD148 are currently lacking.
Lina El Badaoui, Stipo Jurcevic, Yotis A. Senis, Alastair J. Barr   +3 more
wiley   +1 more source

Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of αIIbβ3

, 2008
Polymorphisms in αIIbβ3 are important genetic factors that alter platelet biology and have been associated with susceptibility to thromboembolic disorders.
Satterwhite, Lisa L, Yan, Bin, Ma, Qi, Wang, Huili, Goldschmidt-Clermont, Pascal J   +4 more
core   +1 more source

Multivalent Bi‐Specific Nanoerythrosomes: A Two‐Birds‐One‐Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis

Small, Volume 22, Issue 47, 21 August 2026.
A multivalent bi‐specific nanoerythrosome (mBiNE@tPA) is developed as a “two‐birds‐one‐stone” platform that simultaneously exploits two principal thrombus components. By integrating erythrocyte membrane‐mediated homologous targeting with cRGD‐based active targeting to activated platelets, mBiNE@tPA achieves enhanced thrombus accumulation, triggered ...
Yu Huang, Yilin Yang, Nicole Henry, Boram Gu, Jiahua Wang, Yuanyuan Guo, Colin Longstaff, Simon A. Thom, Yuehua Li, Xiao Yun Xu, Rongjun Chen   +10 more
wiley   +1 more source

In silico analysis of Glanzmann variants of Calf-1 domain of αIIbβ3 integrin revealed dynamic allosteric effect

Scientific Reports, 2017
Integrin αIIbβ3 mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), αIIbβ3 expression / function are impaired.
Matthieu Goguet, Tarun Jairaj Narwani, Rachel Petermann, Vincent Jallu, Alexandre G. de Brevern   +4 more
doaj   +1 more source