Results 51 to 60 of about 2,431,497 (250)

Bitter Substances in the Hop Lupulin

Agricultural Science and Practice, 2014
Aim. To investigate the quantity and structure of α-, β-acids and xanthohumol in lupulin grains of different hop varieties that essentially differ in these biochemical indexes, and also the presence of the substances both in staminate racemes and in the ...
M. Liashenko, L. Protsenko, R. Rudyk, O. Svirchevska   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents [PDF]

, 2014
The authors thank the Royal Society for a University Research Fellowship (ADS), The Carnegie Trust for the Universities of Scotland (LCM), Syngenta/EPSRC (Case award to DGS), GSK/EPSRC (CASE award to SRS), the EU (IEF for CS), and the European Research ...
Morrill, L.C., D'Hollander, A.C.A., O'Riordan, Timothy J. C., O'Riordan, T.J.C., Taylor, James E., Shapland, Peter, Smith, S.R., Morrill, Louis, Shapland, P., Stark, Daniel G., Smith, Siobhan R., Simal Fernandez, Carmen, D'Hollander, Agathe C. A., Stark, D.G., Smith, A.D., Taylor, J.E., Squires, James A., Squires, J.A., Smith, Andrew D., Simal, Carmen   +19 more
core   +1 more source

The distribution of fatty acids between the α′- and β-positions of the glycerophospholipids of buttermilk

Journal of Lipid Research, 1963
Fractionation of buttermilk phospholipids on silicic acid columns gave a cephalin (mixture of amino-N; phospholipids) fraction, in which approximately 29% of the total fatty acids were saturated, and phosphatidyl choline, in which approximately 57% of ...
J.C. Hawke
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress. [PDF]

PLoS ONE, 2015
Lipotoxicity plays an important role in pancreatic β-cell failure during the development of type 2 diabetes. Prolonged exposure of β-cells to elevated free fatty acids level could cause deterioration of β-cell function and induce cell apoptosis ...
Yuren Zhou, Peng Sun, Ting Wang, Kaixian Chen, Weiliang Zhu, Heyao Wang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Novel stereocontrolled syntheses of tashiromine and epitashiromine

Beilstein Journal of Organic Chemistry, 2015
A novel stereocontrolled approach has been developed for the syntheses of tashiromine and epitashiromine alkaloids from cyclooctene β-amino acids. The synthetic concept is based on the azetidinone opening of a bicyclic β-lactam, followed by oxidative ...
Loránd Kiss, Enikő Forró, Ferenc Fülöp   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Correlation of secretory phospholipase-A2 activity and fatty acids in cerebrospinal fluid with liver enzymes tests [PDF]

Journal of Analytical Research in Clinical Medicine, 2016
Introduction: The aim was to determine whether secretory phospholipase-A2 (sPLA2) activity and fatty acids in cerebrospinal fluid (CSF) are correlated with liver enzymes tests.
Sepideh Ghodoosifar, Amir Hossein Jafari-Rouhi, Ali Pashapour, Amir Mehdizadeh, Maghsod Shaaker, Masoud Darabi   +5 more
doaj   +1 more source