Results 141 to 150 of about 3,283,667 (179)

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Phase Behaviour Of Oat β-Glucan/Sodium Caseinate Mixtures [PDF]

Oat β-glucan is a water soluble polysaccharide which has been approved as a functional bioactive ingredient. In this thesis, β-glucan was successfully isolated from oat flour and samples of different molecular weights were produced.
Agbenorhevi, Jacob Kwaku
core   +1 more source

Challenges and Future Directives of Synthetic Biology in Engineering Plant–Microbe Partnerships for Sustainable Agriculture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2491-2519, October 2026.
ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma, Rebaona Reaobaka Molefe‐Madlaliso, Alaba Adewole Adebayo, Oghoye Priscilla Oyedoh, Godfrey Okainemen Oribhabor, Oluwaseun Emmanuel Shittu, Olubukola Oluranti Babalola   +6 more
wiley   +1 more source

Colombiains A–C, Three New Alkaloids From the Soft Coral‐Derived Fungus Cladosporium colombiae CSGL 10M10

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Three new alkaloids, colombiains A–C (1–3), together with eight known ones (4–11) were isolated from the soft coral‐derived fungus Cladosporium colombiae CSGL 10M10. Compounds 6 and 11 exhibited significant cardioprotective activity against OGD/R‐induced injury in H9c2 cardiomyocytes at 10 µM.
Jing Xie, Bing‐Bing Liu, Yang‐Ying Zheng, Jun‐Feng Huan, Xiao‐Yu Tian, Xiu‐Ping Lin, Hui‐Mei Xie, Yuan‐Yuan Cheng, Cui‐Xian Zhang   +8 more
wiley   +1 more source

Actinomycin Analogs From Streptomyces polyantibioticus S4D258: Structural Elucidation and Antiproliferative Activity Against Triple‐Negative Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Fifteen new actinomycin analogs, named actinomycins H1–H15, are identified from S. polyantibioticus S4D258. Actinomycins H7–H15 are truncated actinomycin analogs. Actinomycins H1–H6 and H9 exhibit significant antiproliferative activities against both MDA‐MB‐231 and 4T1 TNBC cells.
He Pang, Xiao‐Min Huang, Usama Ramadan Abdelmohsen, Li Shen, Jun Wu   +4 more
wiley   +1 more source

Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This study evaluates Xiaoyaosan (XYS) for bipolar disorder (BD) using network pharmacology and experimental validation. Molecular docking reveals interactions between active XYS compounds and potential core targets. Animal experiments confirm XYS alleviates BD‐like behaviors in mice by suppressing core targets, elucidating its multi‐target mechanism ...
Man Chen, Nana Ding, Xingmin Qiu, Lan Li, Yali Guo, Rongyanqi Wang, Xiaowei Mo, Tan Zou, Shangzhen Yu, Xiaojuan Li, Jiaxu Chen   +10 more
wiley   +1 more source

Apoptin‐Derived Peptide Alleviates Temporal Lobe Epilepsy (TLE) by Limiting Neuronal Ca2+ Overload Through the HSPA1A–AP2B1 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Epileptogenic stress upregulates HSPA1A, impairs AP2B1 O‐GlcNAcylation and stability, and promotes GluA2 loss‐associated CP‐AMPAR formation and Ca2+ overload. B9 attenuates epileptogenesis by targeting the HSPA1A–AP2B1 axis, restoring AP2B1 O‐GlcNAcylation and stability, preserving GluA2‐associated AMPAR regulation, and reducing pathological Ca2 ...
Zixiao Tan, Qilong Zhai, Jingwen Cui, Xiaoying Gao, Xingan Liu, Zhijie Fan, Yu Liu, Jiahang Sun   +7 more
wiley   +1 more source

Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Microplastics and nanoplastics (MPs/NPs) are emerging environmental neurotoxicants capable of accumulating in the human brain through blood‐brain barrier transcytosis and olfactory transport pathways. Once within the central nervous system, MPs/NPs trigger interconnected mechanisms including NLRP3 inflammasome activation, oxidative stress ...
Alfi Sophian, Asmariani, Erika Ismayani
wiley   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Adeno‐Associated Virus Vector‐Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol‐Induced Seizures

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
Mice received bilateral hippocampal injections of an AAV vector expressing NL2, followed by repeated PTZ administration. NL2 expression in the HPC attenuated seizure progression and reduced c‐Fos expression in the ventral HPC. These findings suggest that AAV‐mediated NL2 expression in the HPC may be a potential therapeutic strategy for seizure control.
Tomohiro Tokutake, Akane Hara, Ayano Murayama, Yuto Mitsuda, Jun Yokose, Yusuke Yano, Yuki Shigetsura, Mika Ito, Naomi Takino, Shinichi Kumagai, Kuniko Shimazaki, Shin‐Ichi Muramatsu, Atsumi Nitta   +12 more
wiley   +1 more source