Results 171 to 180 of about 287,721 (287)

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang   +3 more
wiley   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

open access: yesExperimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela   +4 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas   +1 more
wiley   +1 more source

An allostatic load domain‐specific metabolic profile in young adults: The African‐PREDICT study

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend An allostatic load domain‐specific metabolic profile in young adults: The African‐PREDICT study Abstract Allostatic load scores (ALSs) quantify the cumulative physiological burden of sustained stress across neuro‐endocrine, metabolic, cardiovascular and inflammatory domains; however ALS is heterogeneous in nature.
Nevah Joubert   +4 more
wiley   +1 more source

Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity

open access: yesDevelopmental Psychobiology, Volume 68, Issue 2, March 2026.
ABSTRACT Maternal psychological distress during pregnancy and the early postpartum period is a risk factor for dysregulated affective and regulatory function in young infants. Animal models suggest that perinatal stress may alter offspring development via allopregnanolone (ALLO) exposure.
Denise M. Werchan   +5 more
wiley   +1 more source

Paradoxic septal motion during PEEP ventilation [PDF]

open access: yes, 1989
Daum, S.   +5 more
core   +1 more source

Protein Energy Malnutrition: Opportunities for Cold Plasma Technologies

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
Protein energy malnutrition (PEM) is a major global health concern driven by biological, environmental, and nutritional factors, including gut microbiota imbalance and low protein intake. Cold atmospheric plasma technologies offer promising, sustainable solutions by improving food security, enhancing protein quality and absorption, and modulating gut ...
Karthika Prasad   +6 more
wiley   +1 more source

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