Results 191 to 200 of about 287,721 (287)

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, Volume 36, Issue 2, March 2026.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Alteration in Amino Acid Metabolism After Isocaloric, Energy-Restricted Ketogenic Diet in Women with Overweight and Obesity: Randomized KETO-MINOX Trial. [PDF]

Nutrients
Drabińska-Fois N, Majcher A, Jagielski P, Borowicz-Skoneczny S, Romaszko J.   +4 more
europepmc   +1 more source

Inverse Association Between Betel Quid Use and Diabetes in Rural Bangladesh

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objectives Betel quid is used as a mild stimulant in many parts of South and East Asia and the Pacific. In observational studies, its use has been associated with elevated risk for diabetes, but studies in animal models suggest some component(s) of betel quid could reduce risk.
Kristin K. Sznajder, Mary K. Shenk, Laura Perez, Nurul Alam, Rubhana Raqib, Anjan Kumar, Farjana Haque, Tami Blumenfield, Siobhán M. Cully, Katherine Wander   +9 more
wiley   +1 more source

Amyloid‐related default mode network hyperconnectivity and longitudinal decline in network distinctiveness in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION We investigated stage‐specific alterations in functional connectivity (FC) of the default mode network (DMN) across the Alzheimer's disease (AD) continuum and tested whether early amyloid beta (Aβ)–related changes in within‐DMN FC (DMN‐FCwithin) predicted longitudinal alterations in DMN between‐network connectivity (DMN‐FCbetween).
Woo‐Jin Cha, Evgeny J. Chumin, Dahyun Yi, Min Soo Byun, Joon Hyung Jung, Hyejin Ahn, Gijung Jung, Yu Kyeong Kim, Yun‐Sang Lee, Koung Mi Kang, Chul‐Ho Sohn, Shannon L. Risacher, Olaf Sporns, Kwangsik Nho, Andrew J. Saykin, Dong Young Lee, for the KBASE Research Group   +16 more
wiley   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

A two-sample Mendelian randomization analysis of the impact of GABA receptor subtypes on human height. [PDF]

Medicine (Baltimore)
Chen L, Zeng Z, Wu M, Hu X, Wang Y.
europepmc   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, Volume 73, Issue 1, Page 43-55, February 2026.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Metabolomics Analysis Reveals the Potential Advantage of Artificial Diet-Fed Bombyx Batryticatus in Disease Treatment. [PDF]

Metabolites
Chen H, Feng Y, Pang D, Yang Q, Zou Y, Lin P, Shen G, Xing D.   +7 more
europepmc   +1 more source