Results 61 to 70 of about 35,803 (184)

Intermittent fasting with medium‐chain triglycerides in drug‐resistant epilepsy: A pilot crossover trial

Epilepsia, EarlyView.
Abstract Objective Ketogenic dietary therapies can reduce seizure frequency in drug‐resistant epilepsy, but adherence to the classical ketogenic diet is often poor. Intermittent fasting supplemented with medium‐chain triglycerides (MCTs) may offer a more feasible and less restrictive alternative.
Wiebke Hahn, Emily Falk, Ayla Balzter, Tobias Foer, Shanin Maierhofer, Sophia Jaumann, Sascha Strehlau, Leona Möller, Panagiota‐Eleni Tsalouchidou, Katja Menzler, Lars Timmermann, Susanne Knake   +11 more
wiley   +1 more source

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Electrically Evoked Compound Action Potentials in Spinal Cord Stimulation: Implications for Preclinical Research Models

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives The study aimed to assess the feasibility of recording electrically evoked compound action potentials (ECAPs) from the rat spinal cord. To achieve this, we characterized electrophysiological responses of dorsal column (DC) axons from electrical stimulation and quantified the relationship between ECAP and motor thresholds (ECAPTs and
Birte Elisabeth Dietz, Dave Mugan, Quoc Chi Vuong, Ilona Obara   +3 more
wiley   +1 more source

Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells

EBioMedicine, 2018
In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells.
Sergiy V. Korol, Zhe Jin, Yang Jin, Amol K. Bhandage, Anders Tengholm, Nikhil R. Gandasi, Sebastian Barg, Daniel Espes, Per-Ola Carlsson, Derek Laver, Bryndis Birnir   +10 more
doaj   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

β-aminobutyric acid alleviates the inhibition of production of soybean with exposure to phenanthrene stress via multilayer defense to maintain consistency

Industrial Crops and Products
Polycyclic aromatic hydrocarbons (PAHs), as organic pollutants widely present in the environments, pose a serious threat to the growth and development of industrial crops.
Bowen Wen, Hanlin Liu, Chenning Sha, Miao Wang, Aitong Zheng, Shaoze Zhang, Chenxi Liu, Tongrui Zhang, Xinjie Ma, Siqi Zhu, Chunyuan Ren, Wenjie Zhang, Qiang Zhao, Liang Cao, Yuxian Zhang, Jinpeng Wei, Gaobo Yu   +16 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Nitric Oxide–Mediated Stress Imprint in Potato as an Effect of Exposure to a Priming Agent

Molecular Plant-Microbe Interactions, 2012
We investigated how potato exposed to a chemical agent could activate nitric oxide (NO)-dependent events facilitating more potent defense responses to a subsequent pathogen attack.
Jolanta Floryszak-Wieczorek, Magdalena Arasimowicz-Jelonek, Grzegorz Milczarek, Lukasz Janus, Sylwia Pawlak-Sprada, Dariusz Abramowski, Joanna Deckert, Hanna Billert   +7 more
doaj   +1 more source