Results 221 to 230 of about 1,680,534 (386)

S.6.1 β-catenin is a central mediator in SSc [PDF]

, 2017
Background. β-catenin is the central integrator of canonical Wnt signalling. Since recent evidence suggests a central role of Wnts in fibrosis, we examined the β-catenin/Wnt pathway in SSc and focused on the role of β-catenin in fibroblast activation ...
Abraham, D., Akhmetshina, A., Bergmann, C., Beyer, C., Beyer, C., Busnadiego, O., Carreira, P., Carter, D., de Crombrugghe, B., Dees, C., Dees, C., Dees, C., Distler, A., Distler, A., Distler, J. H. W., Distler, J. H. W., Distler, J. H. W., Distler, O., Distler, O., Distler, O., Fontaine, B., Garcia-Fernandez, R., Horn, A., Horn, A., Kapoor, M., Lagares, D., Lamas, S., Leask, A., Liu, S., MacDougald, O. A., Palumbo, K., Palumbo, K., Rodriguez-Pascual, F., Schett, G., Schett, G., Schett, G., Schramm, A., Shea, B., Shi-Wen, X., Tager, A., Taketo, M. M., Tomcik, M., Venalis, P., Zerr, P., Zerr, P.   +44 more
core  

Additional file 1: of 6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression

, 2019
Figure S1. The calculation process of fractal dimension. Figure S2. Pathway analysis revealed that 6G influenced VEGFa/VEGFR2 pathways. Figure S3. Positive pull-down assay of 6G with VEGFR1 and VEGFR2. Figure S4. Flow cytometry analysis of 6G treated and untreated cells.
Zhong, Weilong, Yang, Wendong, Qin, Yuan, Gu, Wenguang, Xue, Yinyin, Tang, Yuanhao, Xu, Hengwei, Wang, Hongzhi, Zhang, Chao, Wang, Changhua, Sun, Bo, Liu, Yanrong, Liu, Huijuan, Zhou, Honggang, Chen, Shuang, Sun, Tao, Yang, Cheng   +16 more
openaire   +1 more source

Complement C1 and β-catenin in hypertensive arterial remodelling [PDF]

, 2015
Susan J. Allison
openalex   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

β-catenin-driven endomesoderm specification is a Bilateria-specific novelty

Nature Communications
Endomesoderm specification by a maternal β-catenin signal and body axis patterning by interpreting a gradient of zygotic Wnt/β-catenin signalling was suggested to predate the split between Bilateria and their sister clade Cnidaria.
Tatiana Lebedeva, Johan Boström, Stanislav Kremnyov, David Mörsdorf, Isabell Niedermoser, Evgeny Genikhovich, Andreas Hejnol, Igor Adameyko, Grigory Genikhovich   +8 more
doaj   +1 more source

MOESM1 of Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model

, 2018
Additional file 1. Minimum Standards of Reporting Checklist.
Wang, Qian, Zang, Wenhua, Han, Li, Yang, Lei, Ye, Songshan, Ouyang, Jingfeng, Zhang, Chaoyun, Bi, Yuefeng, Zhang, Cuiyue, Bian, Hua   +9 more
openaire   +1 more source

Wnt/β-Catenin Signaling in Development and Disease

Cell, 2006
H. Clevers
semanticscholar   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Additional file 1: Table S1. of Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway

, 2017
Primers for PCR. (DOCX 17Â kb)
Jiang, Xiao-Hua, Xie, Yu-Tao, Cai, Ya-Ping, Ren, Jing, Ma, Tao   +4 more
openaire   +1 more source

MEK inhibitor, PD98059, promotes breast cancer cell migration by inducing β-catenin nuclear accumulation

, 2017
Ying Zhao, Chaochao Ge, Jun Wang, Xiaoxiao Wu, Xiaomin Li, Wei Li, Shasha Wang, Tong Liu, Jiuzhou Hou, Hua Sun, Dong Fang, Songqiang Xie   +11 more
openalex   +2 more sources