Results 261 to 270 of about 262,733 (310)

MAGI3 deficiency unleashes β-catenin conformational change to drive metastatic progression and mTOR inhibitor resistance in ccRCC. [PDF]

Cell Death Dis
Gu S, Wang H, Liu H, Yang Y, Guo Y, Fa P, Zhang L, Yang Y, Qi X, Qin Q, Song R, Yang X, He J.   +12 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

SP1-IKBIP axis promotes the proliferation and invasion of glioma with Wnt/β-catenin associated epithelial-mesenchymal transition. [PDF]

Am J Cancer Res
Liu N, Zhao M, Xu L, Cui Y, Tian Y, Li J, Hu X, Zhang T, Zhen H, Tu Y.   +9 more
europepmc   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth. [PDF]

Commun Biol
Abudureyimu G, Jang HS, Shim J, Kim M, Kang M, Lee D.   +5 more
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Modulation of Wnt/β-Catenin Pathway by Aesculus hippocastanum Extract Enhances Temozolomide Sensitivity in Glioblastoma Cells. [PDF]

J Cell Mol Med
Scuderi SA, Ardizzone A, Mannino D, Palermo N, De Luca F, Catalfamo A, Campolo M, Esposito E, Paterniti I.   +8 more
europepmc   +1 more source

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

Epilepsia Open, EarlyView.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang, Xu Zhang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Wnt/β -catenin signalling shapes macrophage behaviour during injury and repair in the mouse submandibular gland. [PDF]

Sci Rep
Ahmed A, Sachdeva S, Whawell S, Miletich I.   +3 more
europepmc   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source