Results 281 to 290 of about 262,733 (310)

β-Catenin stabilization protects against alveolar hemorrhage through amphiregulin- and BATF-mediated Tregs. [PDF]

open access: yesJCI Insight
Mason F   +11 more
europepmc   +1 more source

Design and synthesis of selective inhibitors for β-catenin/t-cell factor-4 protein-protein interaction

2018
Selective disruption of protein-protein interactions by small molecules is important for probing the structure and dynamic aspects of the cellular network. It can also provide new therapeutic targets. β-Catenin of the canonical Wnt signaling pathway uses the same positively charged groove to bind with T-cell factor (Tcf), cadherin, and adenomatous ...
openaire   +1 more source

Toward better development of protein-protein interaction inhibitors: applications to the β-catenin/t-cell factor protein-protein interaction

2018
The dysregulation of proteinâ€"protein interaction (PPI) networks has been implicated in many diseases. Designing therapeutic small-molecule inhibitors of these interactions is a challenging field for medicinal chemistry. This work advances the techniques for discovering more potent PPI inhibitors through integration of computational and biochemical ...
openaire   +1 more source

Intestinal Crypt Fission and Expression of Î'-Catenin in the Small Intestine of Humans

Gastroenterology, 2017
Zenab M. Dudhwala   +4 more
openaire   +1 more source

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Signal Transduction and Targeted Therapy, 2022
Jiaqi Liu, Yuanyuan Li, Xiaojun Zhang
exaly  

Signal transduction by β-catenin

Current Opinion in Cell Biology, 1995
openaire   +1 more source

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