Results 11 to 20 of about 993,975 (158)

New Polymorph of β-Cyclodextrin with a Higher Bioavailability

Chemistry, 2023
A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy, and thermal analysis.
Askar K. Gatiatulin, Ilya S. Balakhontsev, Sofia M. Talashmanova, Marat A. Ziganshin, Valery V. Gorbatchuk   +4 more
doaj   +2 more sources

Formation and Physico-Chemical Evaluation of Nifedipine-hydroxypropyl-β-cyclodextrin and Nifedipine-methyl-β-cyclodextrin: The Development of Orodispersible Tablets

Pharmaceuticals, 2022
The novelty in this study is the development of new orodispersible tablets containing nifedipine (NIF) as the active ingredient. Initially, the formation of inclusion complexes between nifedipine and two derivatives of beta-cyclodextrin, namely ...
Emma Adriana Ozon, Marian Novac, Daniela Gheorghe, Adina Magdalena Musuc, Mirela Adriana Mitu, Iulian Sarbu, Valentina Anuta, Adriana Rusu, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa   +10 more
doaj   +2 more sources

Chitosan-EDTA-cellulose functionalized with β-cyclodextrin as a pH-sensitive bio-based nanocarrier for curcumin drug delivery [PDF]

Scientific Reports
In this work, chitosan/cellulose/β-cyclodextrin nanostructure was synthesized by cross-linking chitosan and cellulose with EDTA followed by bridging with ethylenediamine-β-cyclodextrin.
Negin Rostami, Mohammad G. Dekamin, Mohammad Reza Naimi-Jamal   +2 more
doaj   +2 more sources

Supramolecular encapsulation of indigo with β-cyclodextrin and Hydroxypropyl-β-cyclodextrin: a sustainable strategy for enhanced solubility, stability, and reducing agent-free dyeing processes [PDF]

Bioresources and Bioprocessing
Indigo, a ubiquitous vat dye in denim manufacturing, is characterized by its exceptionally low aqueous solubility, necessitating chemical reduction to its leuco form using hazardous agents such as sodium dithionite.
Koijam Monica Devi, Nimya Krishnan, Chan-Seo Yeo, Kwon-Young Choi   +3 more
doaj   +2 more sources

Easily accessible 2A-O-Ts-β-cyclodextrin via efficient aqueous conditions [PDF]

RSC Advances
A simple and efficient method for the synthesis of 2A-O-Ts-β-cyclodextrin (2A-O-Ts-β-CD), an important intermediate in cyclodextrin chemistry, is reported.
Golfo G. Kordopati, Maria Tsouna, Gerasimos M. Tsivgoulis   +2 more
doaj   +2 more sources

The Biological Fate of Pharmaceutical Excipient β-Cyclodextrin: Pharmacokinetics, Tissue Distribution, Excretion, and Metabolism of β-Cyclodextrin in Rats

Molecules, 2022
β-cyclodextrin has a unique annular hollow ultrastructure that allows encapsulation of various poorly water-soluble drugs in the resulting cavity, thereby increasing drug stability.
Kunqian Mu, Kaiwen Jiang, Yue Wang, Zihan Zhao, Song Cang, Kaishun Bi, Qing Li, Ran Liu   +7 more
doaj   +1 more source

Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Research in Pharmaceutical Sciences, 2022
Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges
Hadeia Mashaqbeh, Rana Obaidat, Nizar A Al-Shar’i, Tamam El-Elimat, Soraya Alnabulsi   +4 more
doaj   +1 more source

Cyclodextrin: A prospective nanocarrier for the delivery of antibacterial agents against bacteria that are resistant to antibiotics

Heliyon, 2023
Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest molecules and forms host-guest complexation with non-covalent interaction ...
Pranoy Saha, Md Rajdoula Rafe
doaj   +1 more source

Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines

Pharmaceutics, 2022
Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems.
Hamdy Abdelkader, Adel Al Fatease, Zeinab Fathalla, Mai E. Shoman, Heba A. Abou-Taleb, Mohammed A. S. Abourehab   +5 more
doaj   +1 more source

Design, synthesis, and characterization of a series of novel β-cyclodextrin functional monomers

Journal of Chemical Research, 2022
In order to increase its solubility in water and improve β-cyclodextrin combination with guest molecules, chemical modification of β-cyclodextrin is a feasible and effective method.
Zhimin Liu, Zhigang Xu, Liping Ma
doaj   +1 more source