IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception [PDF]
Brain Sciences, 2023 Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the ...
Thiago Caetano Andrade Belo +7 more
doaj +5 more sources
β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling [PDF]
Scientific Reports, 2023 Solar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin ...
Hyung-Su Kim +4 more
doaj +5 more sources
β-Endorphin (an endogenous opioid) inhibits inflammation, oxidative stress and apoptosis via Nrf-2 in asthmatic murine model [PDF]
Scientific Reports, 2023 Asthma, a chronic respiratory disease is characterized by airway inflammation, remodelling, airflow limitation and hyperresponsiveness. At present, it is considered as an umbrella diagnosis consisting several variable clinical presentations (phenotypes ...
Vinita Pandey +4 more
doaj +3 more sources
Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes [PDF]
Frontiers in Pharmacology, 2021 Cynandione A, an acetophenone isolated from Cynanchum Wilfordii Radix, exhibits antineuropathic pain effect. This study further explored the target molecule and signaling mechanisms underlying cynandione-A-induced antineuropathic pain.
Qiao-Qiao Han +5 more
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques [PDF]
International Journal of Endocrinology, 2020 β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues. β-Endorphin induces endothelial dysfunction and is related to insulin resistance.
Taisuke Okano +10 more
doaj +3 more sources
β‐endorphin differentially contributes to food anticipatory activity in male and female mice undergoing activity‐based anorexia [PDF]
Physiological Reports, 2021 Anorexia nervosa (AN) has a lifetime prevalence of up to 4% and a high mortality rate (~5–10%), yet little is known regarding the etiology of this disease.
Caitlin M. Daimon, Shane T. Hentges
doaj +3 more sources
The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors [PDF]
Journal of Neuroinflammation, 2020 Background Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone cancer pain
Evhy Apryani +7 more
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Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway [PDF]
Journal of Neuroinflammation, 2019 Background The G protein-coupled receptor 40 (GPR40), broadly expressed in various tissues such as the spinal cord, exerts multiple physiological functions including pain regulation.
Xiao-Fang Mao +5 more
doaj +3 more sources
Sex differences in binge-like EtOH drinking, corticotropin-releasing hormone and corticosterone: effects of β-endorphin. [PDF]
Addict Biol, 2019 Binge drinking is an increasingly common pattern of risky use associated with numerous health problems, including alcohol use disorders. Because low basal plasma levels of β‐endorphin (β‐E) and an increased β‐E response to alcohol are evident in ...
Nentwig TB +3 more
europepmc +4 more sources
Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism. [PDF]
Int J Mol Sci, 2020 β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist of mu opioid receptors, which can be found throughout the body, brain ...
Pilozzi A, Carro C, Huang X.
europepmc +2 more sources