Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic [PDF]
iScience, 2022 Summary: The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. Symbah-1, a synthetic peptide antibiotic, was identified in a high-throughput antibacterial screen of random ...
Justin R. Randall +7 more
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Chlamydia plasmid-encoded protein Pgp2 is a replication initiator with a unique β-hairpin necessary for iteron-binding and plasmid replication [PDF]
Infection and ImmunityThe virulence plasmid of the obligate intracellular bacterium Chlamydia encodes eight proteins. Among these, Pgp3 is crucial for pathogenicity, and Pgp4 functions as a transcriptional regulator of both plasmid and chromosomal genes.
Danny Wan +3 more
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Dimerization of the β-Hairpin Membrane-Active Cationic Antimicrobial Peptide Capitellacin from Marine Polychaeta: An NMR Structural and Thermodynamic Study [PDF]
BiomoleculesCapitellacin is the β-hairpin membrane-active cationic antimicrobial peptide from the marine polychaeta Capitella teleta. Capitellacin exhibits antibacterial activity, including against drug-resistant strains.
Pavel A. Mironov +7 more
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Diagonal Interactions between Glutamate and Arginine Analogs with Varying Side-Chain Lengths in a β-Hairpin [PDF]
Molecules, 2023 Cross-strand interactions are important for the stability of β-sheet structures. Accordingly, cross-strand diagonal interactions between glutamate and arginine analogs with varying side-chain lengths were studied in a series of β-hairpin peptides.
Nian-Zhi Li +5 more
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Synthesis and antimicrobial activity against Pseudomonas aeruginosa of macrocyclic β-hairpin peptidomimetic antibiotics containing N-methylated amino acids [PDF]
Bioorganic & Medicinal Chemistry, 2016 Antimicrobial resistance among Gram-negative bacteria is a growing problem, fueled by the paucity of new antibiotics that target these microorganisms. One novel family of macrocyclic β-hairpin-shaped peptidomimetics was recently shown to act specifically
Moehle, Kerstin +2 more
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Allosteric signalling in the outer membrane translocation domain of PapC usher [PDF]
eLife, 2014 PapC ushers are outer-membrane proteins enabling assembly and secretion of P pili in uropathogenic E. coli. Their translocation domain is a large β-barrel occluded by a plug domain, which is displaced to allow the translocation of pilus subunits across ...
Irene Farabella +8 more
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β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Amyloid diseases are degenerative pathologies, highly prevalent today because they are closely related to aging, that have in common the erroneous folding of intrinsically disordered proteins (IDPs) which aggregate and lead to cell death. Type 2 Diabetes
Jacopo Lesma +13 more
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Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease [PDF]
Molecular Psychiatry, 2021 Preeti Bakrania +12 more
openalex +2 more sources
Consequences of Peptide Macrocyclization Revealed by Virus-Inspired β-Hairpin Mimetics. [PDF]
ACS Chem BiolBula AL +3 more
europepmc +2 more sources
Conformational features and interaction mechanisms of V<sub>H</sub> H antibodies with β-hairpin CDR3: A case of Nb8-HigB2 interaction. [PDF]
Protein Sci, 2023 Yamamoto K +5 more
europepmc +3 more sources