Results 61 to 70 of about 1,046,387 (249)
Cyclic Peptide Helices: A Hybrid β-Hairpin/β-Helical Supersecondary Structure
, 2016 This communication describes the design and characterization of a new peptide motif that is a hybrid of β-hairpin and β-helical structures. This motif was supported by CD and IR spectrocopies in nonpolar organic solvents and was confirmed by NMR ...
Christopher Brown (258061) +3 more
core +1 more source
Advanced Science, EarlyView.A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou +18 more
wiley +1 more source
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III
Marine Drugs, 2018 Biological activity of the new antimicrobial peptide polyphemusin III from the horseshoe crab Limulus polyphemus was examined against bacterial strains and human cancer, transformed, and normal cell cultures.
Mariana B. Marggraf +7 more
doaj +1 more source
Ultrafast folding and molecular dynamics of a linear hydrophobic β-hairpin
, 2013 The first computational study of the folding and dynamics of a hydrophobic β-hairpin containing a central heterochiral diproline segment is reported. Linear hydrophobic sequences containing centrally positioned diproline motifs, heterochiral (DL/LD) and ...
Upadhyayula Surya Raghavender (473008)
core +1 more source
Advanced Science, EarlyView.This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang +6 more
wiley +1 more source
Induced Fit in Protein Multimerization: The HFBI Case. [PDF]
PLoS Computational Biology, 2016 Hydrophobins, produced by filamentous fungi, are small amphipathic proteins whose biological functions rely on their unique surface-activity properties.
Laura Riccardi, Paolo Mereghetti
doaj +1 more source
, 2016 Insights on β-Hairpin Stability in Aqueous Solution from Peptides with Enforced Type I‘ and Type II‘ β ...
Samuel H. Gellman (621247) +1 more
core +1 more source
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
eLife, 2014 A large group of bacterial virulence autotransporters including AIDA-I from diffusely adhering E. coli (DAEC) and TibA from enterotoxigenic E. coli (ETEC) require hyperglycosylation for functioning.
Qing Yao +10 more
doaj +1 more source
A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes. [PDF]
PLoS ONE, 2018 Which conformational parameters lead to an antibody-affine peptide antigen? And in how many different conformations can we actually present the respective conformational epitope? To provide answers from a chemical point of view, we direct the bending and
Andreas Schrimpf +3 more
doaj +1 more source