Results 81 to 90 of about 1,046,387 (249)
Advanced Science, EarlyView.ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu +10 more
wiley +1 more source
β-hairpin peptides : heme binding, catalysis, and structure in detergent micelles
, 2013 Autonomously folded designed β-hairpin peptides in detergent micelles show peroxidase activity with heme binding. Aromatic–aromatic cross-strand packing interactions that stabilize β-hairpin structures in solution are not strictly required for the ...
Bhattacharjya, Surajit, Mahajan, Mukesh
core +1 more source
Advanced Science, EarlyView.Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang +6 more
wiley +1 more source
Rules for Antiparallel β-Sheet Design: d-Pro-Gly Is Superior to l-Asn-Gly for β-Hairpin Nucleation1
, 2016 Rules for Antiparallel β-Sheet Design: d-Pro-Gly Is Superior to l-Asn-Gly for β-Hairpin ...
Heather E. Stanger (3003294) +1 more
core +1 more source
Advanced Science, EarlyView.In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian +13 more
wiley +1 more source
Advanced Science, EarlyView.In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han +10 more
wiley +1 more source
Infinite pleated β-sheet formed by the β-hairpin Boc-β-Phe-β-Phe-D-Pro-Gly-β-Phe-β-Phe-OMe
, 2002 A β-hairpin conformation and extended β-pleated sheet assembly have been characterized by single crystal x-ray diffraction for the synthetic peptide t-butoxycarbonyl-β-Phe-β-Phe-D-Pro-Gly-β- Phe-β-Phe-methyl ester [β-Phe: (S)-β homophenylalanine].
Balaram, Padmanabhan +2 more
core +1 more source
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling
Advanced Science, EarlyView.Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha +13 more
wiley +1 more source
β-Hairpin stability and folding: Molecular dynamics studies of the first β-hairpin of tendamistat
, 2000 The stability and (un)folding of the 19-residue peptide, SCVTLYQSWRYSQADNGCA, corresponding to the first β-hairpin (residues 10 to 28) of the α-amylase inhibitor tendamistat (PDB entry 3AIT) has been studied by molecular dynamics simulations in explicit ...
NMR-spectroscopie +3 more
core
Thermodynamic and Structural Impact of α,α-Dialkylated Residue Incorporation in a β‑Hairpin Peptide
, 2016 Peptides containing α,α-dialkylated α-amino acids, owing to their ability to disrupt aggregation of β-amyloid proteins, have therapeutic potential in the treatment of neurodegenerative diseases.
George A. Lengyel (1919206) +5 more
core +1 more source