Results 71 to 80 of about 1,046,387 (249)
Hairpin versus Extended DNA Binding of a Substituted β-Alanine Linked Polyamide
, 2016 A series of α-substituted β-alanine (β*) linked polyamides (DbaPyPyPy-β*-PyPyPy) were prepared and examined. This resulted in the observation that while most substituents disrupt DNA binding, (R)-α-methoxy-β-alanine (β(R)-OMe) maintains strong binding ...
Takahiro Ishii (738125) +4 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
VirusesThe Omicron variant and its sub-lineages are the only current circulating SARS-CoV-2 viruses worldwide. In this study, the conformational stability of the isolated Receptor Binding Domain (RBD) of Omicron’s spike protein is examined in detail. The parent
Michael H. Peters
doaj +1 more source
, 2010 10 pags, 8 figs, 1 tabThe cell wall of Streptococcus pneumoniae and several other micro-organisms is decorated with a number of the so-called choline-binding proteins (CBPs) that recognise the choline residues in the bacterial surface by means of highly ...
Sanz, Jesús M. +7 more
core +1 more source
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source
Allosteric signalling in the outer membrane translocation domain of PapC usher
eLife, 2014 PapC ushers are outer-membrane proteins enabling assembly and secretion of P pili in uropathogenic E. coli. Their translocation domain is a large β-barrel occluded by a plug domain, which is displaced to allow the translocation of pilus subunits across ...
Irene Farabella +8 more
doaj +1 more source
Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs [PDF]
, 2010 Theis C, Janssen S, Giegerich R. Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs. In: Moulton V, Singh M, eds. Algorithms in Bioinformatics. 10th international workshop (WABI 2010), proceedings. Lecture Notes in Bioinformatics. Vol
Corinna Theis +7 more
core +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
, 2016 A photochromic azobenzene linker was incorporated as a turn element into an amino acid sequence known to fold into a β-hairpin structure in aqueous solution.
Donald Hilvert (105097) +3 more
core +1 more source
Raising the Speed Limit for β‑Hairpin Formation [PDF]
, 2012 Understanding the folding of the β-hairpin is a crucial step in studying how β-rich proteins fold. We have studied CLN025, an optimized ten residue synthetic peptide, which adopts a compact, well-structured β-hairpin conformation.
Raleigh, Daniel P +3 more
core +1 more source