Results 71 to 80 of about 1,516,213 (305)

Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion. [PDF]

, 2013
Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing
Chang, Yong, Dhar, Gautam, Heiss, John K, Johnson, Reid C, McLean, Meghan M   +4 more
core   +1 more source

CPProtectides: Rapid uptake of well‐folded β‐hairpin peptides with enhanced resistance to intracellular degradation

Peptide Science, 2018
Cell penetrating peptides (CPPs) have emerged as powerful tools for delivering bioactive cargoes, such as biosensors or drugs to intact cells. One limitation of CPPs is their rapid degradation by intracellular proteases.
N. Safa, Jeffery C. Anderson, Manibarathi Vaithiyanathan, Jacob Pettigrew, G. Pappas, Dong-ying Liu, T. Gauthier, Adam T. Melvin   +7 more
semanticscholar   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Aza-Amino Acids Disrupt β-Sheet Secondary Structures

Molecules, 2019
Cα to N substitution in aza-amino acids imposes local conformational constraints, changes in hydrogen bonding properties, and leads to adaptive chirality at the nitrogen atom. These properties can be exploited in mimicry and stabilization of peptide
Michael A. McMechen, Evan L. Willis, Preston C. Gourville, Caroline Proulx   +3 more
doaj   +1 more source

Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides. [PDF]

PLoS Computational Biology, 2013
IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is an intrinsically disordered protein that is coexpressed and cosecreted along with insulin by pancreatic islet β-cells in response to meals.
Chun Wu, Joan-Emma Shea
doaj   +1 more source

Molecular dynamics of folding of secondary structures in Go-type models of proteins

, 2000
We consider six different secondary structures of proteins and construct two types of Go-type off-lattice models: with the steric constraints and without.
Blanco F., Karplus M., Li M. S., Li M. S., Marek Cieplak, Thirumalai D., Trinh Xuan Hoang, Unger R.   +7 more
core   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

The Antimicrobial Peptide Capitellacin: Chemical Synthesis of Analogues to Probe the Role of Disulphide Bridges and Their Replacement with Vinyl Sulphides

Antibiotics
Capitellacin (1) is a 20-residue antimicrobial β-hairpin, produced by the marine polychaeta (segmented worms) Capitella teletai. Since its discovery in 2020, only very limited studies have been undertaken to understand capitellacin’s structure–activity ...
Oscar A. Shepperson, Paul W. R. Harris, Margaret A. Brimble, Alan J. Cameron   +3 more
doaj   +1 more source

Induced Fit in Protein Multimerization: The HFBI Case. [PDF]

PLoS Computational Biology, 2016
Hydrophobins, produced by filamentous fungi, are small amphipathic proteins whose biological functions rely on their unique surface-activity properties.
Laura Riccardi, Paolo Mereghetti
doaj   +1 more source

The Secreted Ribonuclease SRE1 Contributes to Setosphaeria turcica Virulence and Activates Plant Immunity

Frontiers in Microbiology, 2022
During the plant infection process, pathogens can secrete several effectors. Some of the effectors are well-known for their roles in regulating plant immunity and promoting successful pathogen colonization.
Shidao He, Yufei Huang, Yanqiu Sun, Bo Liu, Suna Wang, Yuanhu Xuan, Zenggui Gao   +6 more
doaj   +1 more source