Sulfur Ylides in Skeletal‐Editing—Ring Expansion Reactions
Sulfur ylides (S‐ylides) are emergent diazo surrogates that enable skeletal editing and ring expansion with safer handling and broad functional group tolerance. This perspective covers pioneer works and highlights recent advances in the field, while outlining key challenges and future directions that may redefine the role of S‐ylides in modern ...
Arsala Kamal +3 more
wiley +1 more source
Simulated achievement rate of β-lactams/nacubactam treatment in humans using instantaneous MIC-based PK/PD analysis. [PDF]
Igarashi Y +4 more
europepmc +1 more source
Multidrug‐Resistant Pathogen Clonal Spread in Nigeria: A Systematic Review and Meta‐Analysis
ABSTRACT Background and Aim The rapid dissemination of multidrug‐resistant (MDR) bacterial clones poses a global health threat and limits treatment options. Understanding the dynamics of bacterial clones in Nigeria is essential for developing effective control strategies. This systematic review aimed to track MDR pathogen clones in Nigeria. Methods The
Emmanuel N. Ugbo +5 more
wiley +1 more source
Dual β-lactams for the treatment of Mycobacterium abscessus: a review of the evidence and a call to act against an antibiotic nightmare. [PDF]
Longo BM, Trunfio M, Calcagno A.
europepmc +1 more source
Antimicrobial Resistance in Cancer Care: Challenge and Path Forward
ABSTRACT Introduction Antimicrobial resistance (AMR) is a global health crisis that poses a devastating and specific threat to immunocompromised cancer patients, who are heavily reliant on antibiotics to navigate high‐risk treatments. The rapid emergence of multidrug‐resistant (MDR) pathogens compromises the efficacy of prophylaxis and empirical ...
Majani Edward, Ameh Wisdom Owoicho
wiley +1 more source
ABSTRACT Background and Aims Septic abortion remains a major cause of maternal morbidity and mortality in low‐ and middle‐income countries. This study aimed to determine the prevalence, antibiotic susceptibility profiles, and determinants of septic abortion among women admitted for abortion care in Ugandan satellite teaching hospitals. Methods This two‐
Guled Bashir Gaboose +5 more
wiley +1 more source
Outer membrane permeability of <i>Pseudomonas aeruginosa</i> through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance. [PDF]
Amisano F +7 more
europepmc +1 more source
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo +9 more
wiley +1 more source
Successful treatment of macrolide-resistant <i>Mycobacterium abscessus</i> infection using multi-drug regimens including dual β-lactams and phage therapy: case reports in two children. [PDF]
Shimamura M +9 more
europepmc +1 more source
Resistome flow in global landfill systems
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid‐driven gene mobility. Waste flows and environmental pathways sustain the transboundary resistome networks, accelerating resistance dissemination across ecosystems.
Wenqing Hong +12 more
wiley +1 more source

