Results 71 to 80 of about 50,706 (199)

Nano‐networks via reaction‐induced self‐assembly coordinate spatiotemporal multi‐drug delivery for acute kidney injury therapy

BMEMat, EarlyView.
Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin, Xiao Zhang, Chenxi Wang, Taian Jin, Xinyang Fang, Yixuan Gao, Mengchun Chen, Weiyang Meng, Chang Gao, Wenlu Li, Yuanfeng Li, Yijie Chen, Calvin A. Omolo, Thirumala Govender, Linqi Shi, Yunguang Wang, Yong Liu, Qiang He   +17 more
wiley   +1 more source

The impact of the expression signatures of LncRNAs HBBP1 and XIST on the diagnostic significance of patients with β-Thalassemia

Annals of Hematology
β-thalassemia is an inherited blood disorder with long-term associated complications. The purpose of this study was to evaluate the clinical significance of the lncRNA-HBBP1 and lncRNA-XIST expression profiles in the diagnosis of β-thalassemia patients ...
Abdallah M. Gameel, Shimaa Abdelsattar, Zeinab A. Kasemy, Mai El-Sayad Abd El-Hamid, Eman Masoud Abd ElGayed, Basma M. Abdelgawed, Amira Fathy El-Fiky, Mariam E. Labib, Sabry M. Abdelmageed, Mahmoud Ahmed El Hawy, Yasmin Mohsen, Hanan M. Bedair   +11 more
doaj   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Genetic Manipulation Strategies for β-Thalassemia: A Review

Frontiers in Pediatrics, 2022
Thalassemias are monogenic hematologic diseases that are classified as α- or β-thalassemia according to its quantitative abnormalities of adult α- or β-globin chains.
Nur Atikah Zakaria, Rosnah Bahar, Wan Zaidah Abdullah, Abdul Aziz Mohamed Yusoff, Shaharum Shamsuddin, Shaharum Shamsuddin, Shaharum Shamsuddin, Ridhwan Abdul Wahab, Muhammad Farid Johan   +8 more
doaj   +1 more source

Iron deposits in the knee joints of a thalassemic patient [PDF]

, 2012
The overall prognosis for patients with β-thalassemia has improved considerably during the past decades mainly due to regular blood transfusions, improvements in chelation therapy, and enhanced surveillance with imaging studies examining iron overload ...
Economides, Charalambos P, Hadjigavriel, Michalis, Karantanas, Apostolos, Seimenis, Ioannis, Soteriades, Elpidoforos S   +4 more
core   +2 more sources

Effect of Epigallocatechin‐3‐Gallate on Depression‐Related Cytokines in Thalassemia Patients: Molecular and Cellular Evaluation

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigates the effects of Epigallocatechin‐3‐Gallate (EGCG), a potent anti‐inflammatory polyphenol isolated from Winged Marigold, on cytokine expression linked to depression in β‐thalassemia patients. EGCG demonstrated dose‐dependent suppression of key inflammatory cytokines (IL‐6, IL‐1β, TNF‐α, IFN‐γ) at both gene and protein levels ...
Mohammed N. Salman, Fouad Razzaq Al‐Burki, Hazim Ali Hussein, Laith A. Younus, Fadhil A. Nasser, Hasanain A. A. Almohseni   +5 more
wiley   +1 more source

A validated cellular biobank for β-thalassemia [PDF]

, 2016
Background: Cellular biobanking is a key resource for collaborative networks planning to use same cells in studies aimed at solving a variety of biological and biomedical issues. This approach is of great importance in studies on β-thalassemia, since the
BIANCHI, Nicoletta, BORGATTI, Monica, BREDA, Laura, BREVEGLIERI, Giulia, Chiavilli, Francesco, COSENZA, Lucia Carmela, FINOTTI, Alessia, GAMBARI, Roberto, GAMBERINI, MARIA RITA, LAMPRONTI, Ilaria, Manunza, Laura, Martis, Franca Rosa, Moi, Paolo, Rivella, Stefano, Satta, Stefania, ZUCCATO, Cristina   +15 more
core   +2 more sources

Dupilumab Treatment in Pemphigus: A Report of Three Cases and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Pemphigus vulgaris (PV) and foliaceus (PF) are rare autoimmune blistering diseases traditionally treated with systemic corticosteroids, immunosuppressants, intravenous immunoglobulins, and rituximab. Nonetheless, a subset of patients remains refractory or has contraindications to these conventional therapies.
José Javier Mateos Rico, Marta Gutiérrez Pascual, María Dolores Caro Gutiérrez, Cristina Marcos Rodríguez, Javier de Quadros Malagón, Francisco Javier Vicente Martín   +5 more
wiley   +1 more source

Clinical Insights: Prevalence of β-Thalassemia Mutations (IVSI-5, FSC8/9, and CD41/42) in the Swat District

Journal of Bio-X Research
Background: Thalassemia is a prevalent condition characterized by decreased production or absence of hemoglobin globin chains. There are 2 types of thalassemia, alpha thalassemia and beta thalassemia (β-thalassemia), classified according to defects in ...
Sumaia Saif, Shah Lila, Gulalai Ghani, Murad Ali Rahat, Akhtar Rasool, Muhammad Israr   +5 more
doaj   +1 more source

Postural and balance evaluation in 18-30 years old albaniana β-thalassemia patients [PDF]

, 2016
According to the World Health Organization (WHO), there are at least 70 million thalassemia carriers in the world and in each year 42,000 homozygote children are born.
Kristuli, Aljona, Murataj, Genti, Pano, Genti, Rusi, Dea, Çina, Robert   +4 more
core   +2 more sources