Results 1 to 10 of about 159,798 (214)

Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial. [PDF]

Nat Commun, 2023
β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents. Here the authors report that two-weeks of treatment with the β2-agonist clenbuterol improves insulin-stimulated glucose disposal in healthy young ...
van Beek SMM, Bruls YMH, Vanweert F, Fealy CE, Connell NJ, Schaart G, Moonen-Kornips E, Jörgensen JA, Vaz FM, Smeets ETHC, Joris PJ, Gemmink A, Houtkooper RH, Hesselink MKC, Bengtsson T, Havekes B, Schrauwen P, Hoeks J.   +17 more
europepmc   +2 more sources

The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]

, 2013
The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
core   +1 more source

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K., Blessing, CP, Tammy Liu, Liu, Tammy, Liu, T, Christopher P Blessing, Jackson Edwin K., Liu Tammy, Gul, R, Pulakat, Lakshmi, Pulakat, L, Murat Bastepe, Blessing, Christopher P., Edwin K Jackson, Catherine E Erickson, Rukhsana Gul, Bastepe Murat, Lakshmi Pulakat, Andresen Bradley T., Nguyen, J, Pulakat Lakshmi, Gul, Rukhsana, Andresen, Bradley T., Erickson, CE, Blessing Christopher P., Holowka, David, Nguyen Jenny, Bastepe, Murat, Jackson, EK, Andresen, BT, Gul Rukhsana, Jenny Nguyen, Erickson Catherine E., Bastepe, M, Erickson, Catherine E., Nguyen, Jenny, Bradley T Andresen   +36 more
core   +1 more source

β-blockers reverse agonist-induced β2-AR downregulation regardless of their signaling profile [PDF]

, 2020
Altered β-adrenergic receptor (β-AR) density has been reported in cells, animals, and humans receiving β-blocker treatment. In some cases, β-AR density is upregulated, but in others, it is unaffected or even reduced.
Federica Barbagallo, Caterina Ambrosio, Vanessa Vezzi, Barbagallo F., Tonino Stati, Paola Matarrese, Maccari S., Stati T., Catalano L., Gro M. C., Vezzi V., Sonia Maccari, Ascione B., Molinari P., Maria Cristina Grò, Barbara Ascione, Marano G., Giuseppe Marano, Paola Molinari, Matarrese P., Ambrosio C., Liviana Catalano   +21 more
core   +1 more source

Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA).

, 2015
The clinical pharmacokinetics of AZD3199, an ultra-long-acting β2-agonist, were investigated in healthy volunteers and patients with asthma or chronic obstructive pulmonary disease (COPD)
Jorup, Carin, Kuna, Piotr, Rosenborg, Johan, Bengtsson, Thomas, Bjermer, Leif   +4 more
core   +2 more sources

The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis [PDF]

, 2015
Background: Patterns of inhaled β2-agonist therapy use during severe asthma exacerbations before hospital attendance are poorly understood. Aims: To assess β2-agonist use prior to hospital attendance.
Braithwaite, Irene, Beasley, Richard, Pritchard, Alison, Hancox, Robert J., Shaw, Dominick, Pilcher, Janine, Patel, Mitesh, Sheahan, Davitt, Black, Peter, Weatherall, Mark, Shaw, Dominick E.   +10 more
core   +1 more source

Additional file 1: of Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis

, 2017
The online material of corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: A proof-of-concept systematic review and meta-analysis. (DOCX 80 kb)
Wang, Gang, Zhang, Xin, Zhang, Hong, Wang, Lei, Kang, De, Barnes, Peter   +5 more
openaire   +1 more source

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter, Hunyady, L., Gyombolai, Pál, Boros, E., Turu, G., Turu, Gábor, Gyombolai, P., Hunyady, László   +7 more
core   +1 more source

β2-Adrenergic receptor (β2-AR) agonist formoterol suppresses differentiation of L6 myogenic cells by blocking PI3K–AKT pathway

, 2019
β2-Adrenergic receptor (β2-AR) is implicated in muscle metabolic activities such as glycogen metabolism, glucose uptake, lipolysis and muscle growth. However, the functional role of β2-AR in the differentiation of skeletal muscle is largely unknown. Here,
Kyunghwan Kim, So-Hyeon Kim, Eun-Ju Song, Hyerim Lee, Ji-Hyun Kim, Myung-ju Oh, Sun-Ju Yi, Byung H. Jhun   +7 more
core   +1 more source

Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease

, 2012
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropium are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease.
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source