Results 31 to 40 of about 197,418 (252)

A breath sound analysis in children with cough variant asthma

Allergology International, 2019
Background: Cough variant asthma (CVA) is characterized by a chronic cough and bronchial hyperresponsiveness without confirmation of wheezing. Using a breath sound analyzer, we evaluate the characteristics of breath sound in children with CVA.
Mayumi Enseki, Mariko Nukaga, Hiromi Tadaki, Hideyuki Tabata, Kota Hirai, Masahiko Kato, Hiroyuki Mochizuki   +6 more
doaj   +1 more source

The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis [PDF]

, 2015
Background: Patterns of inhaled β2-agonist therapy use during severe asthma exacerbations before hospital attendance are poorly understood. Aims: To assess β2-agonist use prior to hospital attendance.
Braithwaite, Irene, Beasley, Richard, Pritchard, Alison, Hancox, Robert J., Shaw, Dominick, Pilcher, Janine, Patel, Mitesh, Sheahan, Davitt, Black, Peter, Weatherall, Mark, Shaw, Dominick E.   +10 more
core   +1 more source

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter, Hunyady, L., Gyombolai, Pál, Boros, E., Turu, G., Turu, Gábor, Gyombolai, P., Hunyady, László   +7 more
core   +1 more source

Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae [PDF]

, 2010
Includes abstract.Includes bibliographical references (leaves 183-184).G-proton coupled receptors (GPCRs) are excellent drug targets that occupy a central position in the physiology of insects and are involved in transmission of signal from the ...
Mugumbate, Grace Chitima
core   +1 more source

Short-acting bronchodilators for the management of acute exacerbations of chronic obstructive pulmonary disease in the hospital setting: systematic review

Systematic Reviews, 2018
Background Currently, there is a lack of guidelines for the use of short-acting bronchodilators (SABD) in people admitted to hospital for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), despite routine use in practice and risk of ...
Zoe A. Kopsaftis, Nur S. Sulaiman, Oliver D. Mountain, Kristin V. Carson-Chahhoud, Paddy A. Phillips, Brian J. Smith   +5 more
doaj   +1 more source

Effects of β2-agonists and exercise on β2-adrenergic receptor signaling in skeletal muscles

Journal of Physical Fitness and Sports Medicine, 2012
In this review, we discuss the anabolic and metabolic responses of skeletal muscles to β2-agonists and exercise. β2-agonists increase muscle mass, particularly in fast-twitch muscles.
Shogo Sato, Ken Shirato, Takako Kizaki, Hideki Ohno, Kaoru Tachiyashiki, Kazuhiko Imaizumi   +5 more
doaj   +1 more source

Computational design and characterization of nanobody-derived peptides that stabilize the active conformation of the β2-adrenergic receptor (β2-AR) [PDF]

, 2019
This study aimed to design and functionally characterize peptide mimetics of the nanobody (Nb) related to the β2-adrenergic receptor (β2-AR) (nanobody-derived peptide, NDP).
Vrecl, Milka, Senćanski, Milan V., Veljković, Nevena, Šnajder, Marko, Veljković, Nevena V., Sencanski, Milan, Glisic, Sanja, Poklar Ulrih, Nataša, Mavri, Janez   +8 more
core   +1 more source

Circadian Rhythms in the CNS and Peripheral Clock Disorders: Function of Clock Genes: Influence of Medication for Bronchial Asthma on Circadian Gene

Journal of Pharmacological Sciences, 2007
Bronchial asthma is a chronic inflammatory disorder of the airways, in which inflammation causes bronchial hyper-responsiveness and flow limitation in the presence of various stimuli.
Naoto Burioka, Yasushi Fukuoka, Miyako Takata, Masahiro Endo, Masanori Miyata, Hiroki Chikumi, Katsuyuki Tomita, Masahiro Kodani, Hirokazu Touge, Kenichi Takeda, Takashi Sumikawa, Kousuke Yamaguchi, Yasuto Ueda, Hirofumi Nakazaki, Hisashi Suyama, Akira Yamasaki, Hiroyuki Sano, Tadashi Igishi, Eiji Shimizu   +18 more
doaj   +1 more source

Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations

Marine Drugs, 2020
Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders.
Jierong Wen, David J. Adams, Andrew Hung
doaj   +1 more source

Acute Effects of Single Versus Combined Inhaled β2-Agonists Salbutamol and Formoterol on Time Trial Performance, Lung Function, Metabolic and Endocrine Variables

Sports Medicine - Open, 2023
Background High prevalence rates of β2-agonist use among athletes in competitive sports makes it tempting to speculate that illegitimate use of β2-agonists boosts performance. However, data regarding the potential performance-enhancing effects of inhaled
Daniel A. Bizjak, Dorle Nussbaumer, Kay Winkert, Gunnar Treff, Kensuke Takabajashi, Lennart Mentz, Franziska Schober, Jasmine-Lèonike Buhl, Lucas John, Jens Dreyhaupt, Luise Steeb, Lukas C. Harps, Maria K. Parr, Patrick Diel, Martina Zügel, Jürgen M. Steinacker   +15 more
doaj   +1 more source