Results 21 to 30 of about 159,798 (214)

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

ДИАГНОСТИКА, ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА И ЛЕЧЕНИЕ БРОНХООБСТРУКТИВНОГО СИНДРОМА: МЕСТО КОМБИНИРОВАННЫХ ПРЕПАРАТОВ Β2-АГОНИСТОВ И ИНГАЛЯЦИОННЫХ ГЛЮКОКОРТИКОСТЕРОИДОВ

, 2011
Diagnosis, differentiation and management of bronchial obstructive syndrome: a role of β2-agonists and inhaled steroids combined in a single inhalerДиагностика, дифференциальная диагностика и лечение бронхообструктивного синдрома: место комбинированных ...
A. R. Tatarsky, А. Р. Татарский   +1 more
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

β2-adrenoceptor agonist-induced upregulation of tachykinin NK2 receptor expression and function in airway smooth muscle

, 1999
Neurokinin A (NKA) induces bronchoconstriction mediated by tachykinin NK2 receptors in animals and humans, and may be increased in asthma. Because β2-adrenoceptor agonists are the most widely used bronchodilators in asthma, we investigated the effects of
Zaagsma, J, Barnes, PJ, Zaagsma, Hans, Johan Zaagsma, Katsunuma, T, Roffel, A.F., Elzinga, C.R.S., Elzinga, CRS, Barnes, P.J., Peter J. Barnes, Mak, J.C.W., Roffel, A.F, Toshio Katsunuma, Ad F. Roffel, Elzinga, C.R S, Katsunuma, T., Roffel, AF, Carolina R. S. Elzinga, Mak, JCW, Zaagsma, Johan, Barnes, P.J, Judith C. W. Mak, Mak, J.CW   +22 more
core   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Cadogan, Elaine, Jordan, Stephen, Connolly, Stephen, Ingall, Anthony, Stocks, Michael, Paine, Stuart, Christie, Jadeen, Fisher, Adrian, Mullen, Alex, Lawson, Mandy, Alcaraz, Lilian, Cook, Anthony, Dixon, John, Nicholls, David, Humphries, Alexander, Pairaudeau, Garry, Bailey, Andrew, Flaherty, Alice, School of Pharmacy, The University of Nottingham, AstraZeneca R&D Charnwood, Bonnert, Roger, Young, Alan   +21 more
core   +1 more source

Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI

, 2021
The extracellular domain of the nicotinic acetylcholine receptor isoforms formed by three α4 and two β2 subunits ((α4)3(β2)2 nAChR) harbors two high-affinity canonical acetylcholine (ACh)-binding sites located in the two α4:β2 intersubunit interfaces ...
Akk, Gustav, Peredia, Eloisa, Deba, Farah, Hamouda, Ayman K., Hamouda, Ayman K, Munoz, Kemburli   +5 more
core   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura, Tomomi Yamaguchi, Tomoki Kosho   +2 more
wiley   +1 more source