Results 11 to 20 of about 197,418 (252)
Animal Cells and Systems, 2019 β2-Adrenergic receptor (β2-AR) is implicated in muscle metabolic activities such as glycogen metabolism, glucose uptake, lipolysis and muscle growth. However, the functional role of β2-AR in the differentiation of skeletal muscle is largely unknown. Here,
So-Hyeon Kim +7 more
doaj +2 more sources
MetabolitesStress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction (IUGR) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic
Rachel L. Gibbs +9 more
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Potentiation of a neuronal nicotinic receptor via pseudo-agonist site [PDF]
, 2019 Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)3(β2)2 and (α4)2(β2)3, each with distinct pharmacological signatures; (α4)3(β2)2 receptors are strongly potentiated by the drug NS9283, whereas (α4)
Mazzaferro, Simone +2 more
core +7 more sources
Respiratory Research, 2020 Glucocorticoids (GCs) and β2-adrenergic receptor (β2AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflammation and airway hyperresponsiveness that
Elena Chung +8 more
doaj +1 more source
Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA). [Elektronisk resurs] [PDF]
, 2015 The clinical pharmacokinetics of AZD3199, an ultra-long-acting β2-agonist, were investigated in healthy volunteers and patients with asthma or chronic obstructive pulmonary disease (COPD)
Jorup, Carin +5 more
core +2 more sources
The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]
, 2013 The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
core +1 more source
Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease [PDF]
, 2012 BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropium are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease.
Christopher J Cates +3 more
core +1 more source
Measuring asthma control in group studies: do we need airway calibre and rescue β2-agonist use? [PDF]
, 2001 Collection of airway calibre and β2-agonist data in large clinical trials and epidemiological surveys is sometimes difficult and may be an inefficient use of resources.
ROBERTS, J.N. +5 more
core +1 more source
Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI [PDF]
, 2021 The extracellular domain of the nicotinic acetylcholine receptor isoforms formed by three α4 and two β2 subunits ((α4)3(β2)2 nAChR) harbors two high-affinity canonical acetylcholine (ACh)-binding sites located in the two α4:β2 intersubunit interfaces ...
Akk, Gustav +5 more
core +4 more sources
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]
, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K. +36 more
core +2 more sources