Results 201 to 210 of about 1,803,893 (333)

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source

Functional heterogeneity of γδ T cells in colorectal cancer. [PDF]

Front Immunol
Vaz-Pinto AM, Prinz I.
europepmc   +1 more source

Three‐Layer‐Structured Garnet‐Dominant Composite Solid Electrolyte for Solid‐State Batteries

Carbon Energy, EarlyView.
The three‐layer‐structured garnet‐dominant composite solid electrolyte (GD‐CSE) is designed for solid‐state batteries. The GD‐CSE is composed of over 80 wt. % contents of LGLZO. This three‐layer CSE has high ionic conductivity and high potential stability.
Wooyoung Lee, Jongmin Lee, Seohye Jeon, Joonsoo Kim, Ji Haeng Yu, Kyong Sik Yun, Jung Hyun Lee, Jungjoon Yoo, Tae Woo Kim, Sinho Choi, Yu‐Jin Han, Sang‐Hoon Park, Boyun Jang, Daeil Kim   +13 more
wiley   +1 more source

A clinical-grade automated platform for the manufacturing of CAR-γδ T cells for immunotherapy. [PDF]

Front Immunol
Kuska J, Kostyra J, Pinot L, Egorov E, Jelveh N, Martinez Carrera LA, Zhang C, Khorkova S, Assenmacher M, Orentas R, Mueller S, Hidalgo JV.   +11 more
europepmc   +1 more source

Deciphering the phenotypic and functional complexity of γδ T cells

reservedGamma delta (γδ) T cells are the prototypic members of the family of unconventional T cells. γδ T cells are defined by the expression of the γδ T cell receptor (TCR), which shows human leukocyte antigen (HLA)-unrestricted activity. Moreover, γδ T
FOGLIETTA, BEATRICE
core  

Beyond Activity: The Unified Framework of the Sabatier Principle to Guide Rational Design of Durable and Active Electrocatalysts

Carbon Energy, EarlyView.
In this review, a unified framework of the Sabatier principle is applied to a diverse range of catalytic and electrocatalytic systems for advanced clean energy technologies, with a particular focus on the oxygen reduction reaction (ORR). This approach will guide the design and development of highly active and stable catalysts for fuel cells ...
Wanying Zhang, Quan Zhou, Xuanxuan Bi, Luo Luo, Yunxiang Cheng, Rongyue Wang, Zhongwei Chen   +6 more
wiley   +1 more source

γδ T cells at the interface of innate and adaptive immunity in cancer. [PDF]

J Immunother Cancer
Solé Casaramona A, Bachmann MF, Sevick-Muraca E, O Mohsen M.   +3 more
europepmc   +1 more source