Results 181 to 190 of about 1,803,893 (333)

Unraveling the role of γδ T cells in the pathogenesis of an oncogenic avian herpesvirus

mBio
Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (γδ) T cells.
Mohammad A. Sabsabi, Ahmed Kheimar, Yu You, Dominik von La Roche, Sonja Härtle, Thomas W. Göbel, Theresa von Heyl, Benjamin Schusser, Benedikt B. Kaufer   +8 more
doaj   +1 more source

Tuning Interfacial Water Dynamics via Gd‐Doped Cu2O for High‐Rate Selective CO2‐to‐Ethanol Conversion

Advanced Energy Materials, EarlyView.
A Gd‐doped Cu2O electrocatalyst disrupts rigid interfacial hydrogen‐bonding networks, creating a free‐water‐rich microenvironment. This accelerates proton‐coupled electron transfer, enabling selective high‐rate CO2‐to‐ethanol conversion with 48.5% Faradaic efficiency at industrially relevant current densities.
Hyunwoo Kim, Hyo Sang Jeon, Eugene Huh, Man Ho Han, Hyeon‐Seok Bang, Junho Lee, Jae‐Young Choi, Dong Ki Lee, Kyeongsu Kim, Byoung Koun Min, Woong Hee Lee, Hyung‐Suk Oh   +11 more
wiley   +1 more source

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

, 2023
γδ T cells are potent anticancer effectors with the potential to target tumours broadly, independent of patient-specific neoantigens or human leukocyte antigen background 1-5.
Mamedov, Murad R, Rios, Anne C, Marson, Alexander, Sebestyen, Zsolt, Sahu, Avinash Das, Adams, Erin J, Freimer, Jacob W, Ramesh, Amrita, Meringa, Angelo D, Nguyen, Vinh Q, Takeshima, Kirsten A, Arce, Maya M, Kuball, Jürgen, Chen, Peixin Amy, Hanspers, Kristina, Pritchard, Jonathan K, Ota, Mineto, Vedova, Shane   +17 more
core  

Recent Advances in Functional Liver Volumetry: Emphasis on 99mTc‐GSA SPECT/CT Fusion Imaging

Annals of Gastroenterological Surgery, EarlyView.
Functional liver volumetry enables more accurate assessment of the future liver remnant by integrating anatomical and functional information, improving risk stratification before major hepatectomy. Among available techniques, 99mTc‐GSA SPECT/CT fusion imaging enables precise regional functional assessment and more reliable prediction of post ...
Toru Beppu, Toshiro Masuda, Yasunori Nagayama, Hidetoshi Nitta, Hiromitsu Hayashi   +4 more
wiley   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, EarlyView.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

T-Cell Receptor γδ Bearing Cells in Normal Human Skin

, 1990
T-cell antigen receptors (TCR) are divided into common αβ and less common γδ types. In the murine skin, TCR γδ+ cells have been reported to form the great majority of epidermal T lymphocytes.
Kapsenberg, Martien L., Teunissen, M. B., Jannie Borst, Cairo, I., Krieg, Suze R., Krieg, S. R., Irina Cairo, Jan D. Bos, Teunissen, Marcel B.M., Suze R. Krieg, Martien L. Kapsenberg, Pranab K. Das, Marcel B.M. Teunissen, Bos, Jan D., Das, P. K., Bos, J. D., Kapsenberg, M. L., Das, Pranab K., Cairo, Irina, Borst, Jannie, Borst, J.   +20 more
core   +1 more source

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source