Results 191 to 200 of about 29,353 (245)

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond. [PDF]

Front Immunol
Fang X, Yan S, He L, Deng C.
europepmc   +1 more source

Deterministic Fiber‐Optic Spectral Engineering Enables Three‐Color Multiplexed Two‐Photon Microscopy

Laser &Photonics Reviews, EarlyView.
A simulation‐guided spectral‐engineering framework maps the nonlinear parameter space of a fiber laser platform to identify balanced three‐band excitation states. The resulting 960, 1080, and 1175 nm femtosecond pulses deliver nJ‐level energies for low‐cross‐talk chromatically multiplexed two‐photon microscopy.
Marvin Edelmann, Andreu Matamoros‐Angles, Mohsin Shafiq, Mikhail Pergament, Franz X. Kärtner, Markus Glatzel   +5 more
wiley   +1 more source

Ultralow‐Backscattering Induced Mode Splitting in Chipscale Valley Photonic Topological Cavities

Laser &Photonics Reviews, EarlyView.
The proposed in‐situ metrology based on mode splitting quantifies the ultralow backscattering of topological valley edge states at a single sharp corner, demonstrating near‐lossless topological transport (0.09 dB/corner) on a silicon chip. This work provides insight into the robustness of the photonic valley system and shows the great potential of ...
Kaiji Chen, Wenhao Wang, Yi Ji Tan, Zhonglei Shen, Ridong Jia, Ranjan Singh   +5 more
wiley   +1 more source

The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis. [PDF]

Front Immunol
Song Y, Guo F, Dai H, Zhou X, Dong S, Zhang H, Qian Z, Li B, Wang X, Xu T, Wang H.   +10 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

The pulmonary commensal Lactobacillus regulated lung γδ T cells to enhance resistance against bacterial infections. [PDF]

Microbiome
Zhang H, Bao X, Li C, Liang Y, Pan N, Fu Y, Ma B, Wang T, Chen J, Zhang L, Wang X.   +10 more
europepmc   +1 more source

Associations of Monocyte Glucocerebrosidase with Cognition and Cholinergic Innervation in GBA1 Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase). Parkinson's disease (PD) patients carrying a GBA1 variant (GBA‐PD) exhibit faster cognitive decline, linked to cholinergic degeneration. Objectives The aim was to investigate whether GCase activity, measured in monocytes, correlates with cognitive dysfunction or ...
Sofie Slingerland, Sygrid van der Zee, Sven C.D. van Ijzendoorn, Anne C. Slomp, Jeffrey M. Boertien, Sanne K. Meles, Arjan Kol, Marie Geerlings, Teus van Laar   +8 more
wiley   +1 more source

TIM-3 and γδ T cells: new players in breast cancer dissemination. [PDF]

EMBO J
Galluzzi L, Galassi C, Wiest DL.
europepmc   +1 more source