Results 281 to 290 of about 75,241 (309)

The Stiff-Person Syndrome: An Autoimmune Disorder Affecting Neurotransmission of γ-Aminobutyric Acid

open access: bronze, 1999
Lucien M. Levy   +2 more
openalex   +1 more source

Cortico‐cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization

open access: yesEpilepsia, EarlyView.
Abstract Cortico‐cortical evoked potentials (CCEPs) are an active electrophysiological technique used during intracranial electroencephalography to evaluate the effective connectivity and influence of therapeutic stimulation between distinct cortical regions and pinpoint epileptogenic zones (EZs) in patients with epilepsy.
Zekai Qiang   +7 more
wiley   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications. 1. Use of the EEG in drug development and characteristics of the model

open access: yesEpilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof‐of‐principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalography (EEG) response (PPR) as a surrogate for seizures, is currently the only human model that allows POP trials of investigational compounds after ...
Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus

open access: yesEpilepsia, EarlyView.
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo   +3 more
wiley   +1 more source

Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations

open access: yesEpilepsia, EarlyView.
Abstract Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures,
Enes Akyuz   +2 more
wiley   +1 more source

GABRA2‐related encephalopathy: Identification of two phenotypes with distinctive electroclinical features

open access: yesEpilepsia, EarlyView.
Abstract Pathogenic variants in γ‐aminobutyric acid type A (GABAA) receptor subunit genes are increasingly associated with epilepsy and neurodevelopmental disorders. Pathogenic variants in GABRA2, encoding the α‐2 subunit of GABAA receptors, have been recently reported.
Marie Adamo‐Croux   +15 more
wiley   +1 more source

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