Results 81 to 90 of about 1,820,241 (196)

Delta opioid receptors are essential to the antiallodynic action of Β-mimetics in a model of neuropathic pain

Molecular Pain, 2020
The adrenergic system, because of its reported implication in pain mechanisms, may be a potential target for chronic pain treatment. We previously demonstrated that β 2 -adrenoceptors (β 2 -ARs) are essential for neuropathic pain treatment by ...
Mélanie Kremer, Salim Megat, Yohann Bohren, Xavier Wurtz, Laurent Nexon, Rhian Alice Ceredig, Stéphane Doridot, Dominique Massotte, Eric Salvat, Ipek Yalcin, Michel Barrot   +10 more
doaj   +1 more source

Cannabis Use Among People Aged 65 and Older: Results From an Intercept Survey in New York City

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Cannabis use among older adults has increased in recent years. Age‐related physiological changes, socio‐ecological factors, and medications may exacerbate potential adverse effects of cannabis and complicate the detection of cannabis use disorder (CUD) in older adults.
Benjamin H. Han, Krish Jagasia, Tyler Simi, Nina Abukahok, Joseph J. Palamar   +4 more
wiley   +1 more source

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ-Opioid Receptor Ligands

, 2016
Herein, we report that N-alkyl-octahydroisoquinolin-1-one-8-carboxamides are a novel class of readily synthesized, selective κ-opioid receptor (KOR) ligands. A striking feature of this class of compounds is the absence of any basic nitrogen atoms.
Thuy B. Tran (2276566), Kevin J. Frankowski (1514284), Partha Ghosh (1600147), Vincent Setola (391871), Jeffrey Aubé (1314141), Bryan L. Roth (143613)   +5 more
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Temporal Associations Between Physiological Sleep and Next‐Day Pain Intensity in Individuals With Activity‐Limiting Chronic Pain: A Multiple Night At‐Home Ear‐EEG Sleep‐Monitoring Study

Journal of Sleep Research, EarlyView.
ABSTRACT Chronic pain and sleep disturbances frequently co‐occur. However, most prior research relies on self‐report or actigraphy, which reflect behavioural aspects of sleep but provide only limited insight into the underlying sleep physiology. In this pre‐registered prospective observational study (NCT06368531), we investigated within‐person night‐to‐
Henrik Bjarke Vaegter, Nannapas Banluesombatkul, Maria Louise Stage Olsen, Kübra Kilic, Mia Dyhr Thomsen, Martin Christian Hemmsen, Preben Kidmose, Jonas Bloch Thorlund   +7 more
wiley   +1 more source

Structure of the human κ-opioid receptor in complex with JDTic [PDF]

, 2012
Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive, mood, and—in the case of κ-opioid receptor (κ-OR)—dysphoria and psychotomimesis. Here we report
Cherezov, Vadim, Daniel Wacker, Vadim Cherezov, Roth, Bryan, Mileni, Mauro, Carroll, F. Ivy, Vsevolod Katritch, Raymond C. Stevens, Huixian Wu, Philip D. Mosier, Huang, Xi-Ping, Wu, Huixian, F. Ivy Carroll, S. Wayne Mascarella, Westkaemper, Richard B., Roth, Bryan L., Mascarella, S. Wayne, Aaron A. Thompson, Katritch, Vsevolod, Eyal Vardy, Wacker, Daniel, Liu, Wei, Huang, Xi Ping, Han, Gye Won, Thompson, Aaron A., Vardy, Eyal, Gye Won Han, Xi-Ping Huang, Mosier, Philip D., Stevens, Raymond C., Richard B. Westkaemper, Bryan L. Roth, Mauro Mileni, Wei Liu   +33 more
core   +1 more source

8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

Beilstein Journal of Organic Chemistry, 2007
There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds.
Thomas A. Munro, Katharine K. Duncan, Richard J. Staples, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon Jr., Bruce M. Cohen   +7 more
doaj   +1 more source

Synergistic Interaction Between Fentanyl and a Tramadol:Paracetamol Combination on the Inhibition of Nociception in Mice

Journal of Pharmacological Sciences, 2012
Multimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral
Víctor Fernández-Dueñas, Raquel Poveda, Sílvia Sánchez, Francisco Ciruela   +3 more
doaj   +1 more source

The risk and resilience factors associated with secondary traumatic stress in school personnel: A scoping review

British Journal of Educational Psychology, Volume 96, Issue 4, Page 1634-1667, December 2026.
Abstract Background School personnel bear the emotional burden of students' trauma. Secondary traumatic stress (STS), resulting from indirect trauma exposure, impacts well‐being and job performance through PTSD‐like symptoms, making addressing STS in schools a critical priority.
Paul Gordon, Lisa Jane Rodgers, Martin Dempster, Donncha Hanna   +3 more
wiley   +1 more source

The Overexpression of Bcl-2 Antagonizes the Proapoptotic Function of the Kappa-Opioid Receptor

, 2003
Opioid receptors are G-protein-coupled cell-surface receptors that are mainly expressed in neuronal cells. Stimulation of the K-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis.
NAISUM WONG, CATHERINE TEIMEI DIAO, Wong, T, TAKMING WONG, Wong, N, Diao, CT   +5 more
core   +1 more source