Results 101 to 110 of about 1,820,241 (196)

The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain

Cell Reports Medicine
Summary: The shortfall in new analgesic agents is a major impediment to reducing reliance on opioid medications for control of severe pain. In both animals and man, attenuating nociceptive transmission from primary afferent neurons with a μ-opioid ...
Ellen S. Staedtler, Matthew R. Sapio, Diana M. King, Dragan Maric, Andre Ghetti, Andrew J. Mannes, Michael J. Iadarola   +6 more
doaj   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, Volume 100, Issue 5, Page 948-961, November 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

The κ-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety

, 2013
The kappa (κ) opioid system appears to interact with nicotine in the modulation of locomotion and addiction related processes. In this study we have investigated the possible implication of the κ-opioid system in the effects of nicotine on anxiety and ...
Marco, Eva María, Pérez-Álvarez, L., Llorente, Ricardo, Guaza, Carmen, Viveros, M. Paz, Moreno, Enrique   +5 more
core   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, Volume 100, Issue 5, Page 1023-1027, November 2026.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Differential Effects of μ-, δ-, and κ-Opioid Receptor Agonists on Mechanosensitive Gastric Vagal Afferent Fibers in the Rat

, 2000
Single-fiber recordings were made from the decentralized right cervical vagus nerve (hyponodosal) of the rat. A total of 56 afferent fibers that responded to gastric distension (GD) were studied: 6 fibers were stimulated by phasic balloon GD, 50 by ...
Noriyuki Ozaki, G. F. Gebhart, J. N. Sengupta   +2 more
core   +1 more source

Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa‐Opioid and 5‐HT2A/2C Receptor Agonists in Mice

Neuropsychopharmacology Reports
Aim The regulation of new psychoactive and dangerous abused substances is very important for the prevention of drug abuse. A simple and effective evaluation method using laboratory animals is needed to regulate designated drugs with high accuracy and ...
Hideaki Kato, Yoshimi Ichimaru, Masaaki Kurihara, Koushirou Sogawa, Masahiko Funada, Tsutomu Suzuki   +5 more
doaj   +1 more source

Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure

Molecular Pain, 2016
Background Opioids have become the mainstay for treatment of moderate to severe pain and are commonly used to treat surgical pain. While opioid administration has been shown to cause opioid-induced hyperalgesia and tolerance, interactions between opioid ...
Peyman Sahbaie MD, De-Yong Liang PhD, Xiao-You Shi MD, Yuan Sun PhD, J David Clark MD, PhD   +4 more
doaj   +1 more source

Potential use of early alterations in μ and δ opioid receptors as a predictive index for delayed brain ischemic damage

Neurobiology of Disease, 2003
We previously reported differential alterations of the μ, δ, and κ opioid receptors following permanent middle cerebral artery occlusion. The present work studied the evolution of opioid receptor types following transient focal cerebral ischemia (tMCAO),
Hervé Boutin, Philippe Jauzac, Eric T. MacKenzie, François Dauphin   +3 more
doaj   +1 more source

Impact of parameter settings on the estimation of drug exposure with the individualized dispensing patterns method

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3982-3991, November 2026.
Aim To assess the impact of parameter settings when using the individualized dispensing patterns (IDP) method to estimate exposure duration from dispensing data. Methods We conducted a cohort study using a 2% representative sample of the French healthcare insurance database from 2013 to 2022.
Laëtitia Gosselin, Clara Lévy, Noémie Sève, Thierry Blanchon, Marianne Sarazin, Louise Rossignol, Maryse Lapeyre‐Mestre, Nathanaël Lapidus, Olivier Steichen   +8 more
wiley   +1 more source

Artificial Intelligence in Clinical Supervision and Training of Psychologists and Other Mental Health Professionals: A Scoping Review

Clinical Psychology &Psychotherapy, Volume 33, Issue 6, November/December 2026.
ABSTRACT Background Clinical supervision is fundamental to the development of competent mental health professionals; however, established approaches are limited by challenges in scalability, direct observation and timely feedback. Artificial intelligence has emerged as a potential adjunct to supervision and clinical training, yet the full scope of ...
Jorge Victor Nascimento da Silva, Paulo Vinicius Silva Ferreira, Pedro Paulo Salustiano dos Santos, Maria Amélia Penido   +3 more
wiley   +1 more source