Results 111 to 120 of about 1,820,241 (196)

Dynamic Modeling of G Protein-Biased κ-Opioid Receptor Agonism

DYNAMIC MODELING OF G PROTEIN-BIASED Κ-OPIOID RECEPTOR AGONISM Dynamic Modeling of G Protein-Biased κ-Opioid Receptor Agonism / Doering, Niklas Piet (Rights reserved) (-
Doering, Niklas Piet
core  

Involvement of the κ-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats

, 2013
We have studied the possible interaction between three selective opioid-receptor antagonists, nor-binaltorphimine (NB: κ) (5 mg/kg), cyprodime (CY: μ) (10 mg/kg) and naltrindole (NTI: δ) (1 mg/kg), and the cannabinoid receptor agonist CP 55,940, in the ...
Marco, Eva María, Fernández, Beatriz, Guaza, Carmen, Rubio, Marina, Schmidhammer, Helmut, Biscaia, M., Viveros, M. Paz, Marín, Susana   +7 more
core   +1 more source

Effectiveness of immersive virtual reality‐based interventions for alleviating peri‐ and post‐procedural pain and anxiety in gynecologic settings: A systematic review and meta‐analysis of randomized controlled trials

International Journal of Gynecology &Obstetrics, Volume 175, Issue 2, Page 565-583, November 2026.
Abstract Background Non‐pharmacological and complementary therapeutic, notably immersive virtual reality‐based interventions (IVR), could alleviate pain and anxiety associated with gynecologic procedures. Objective To evaluate the effectiveness of IVR in reducing peri‐ and post‐procedural pain and anxiety in gynecologic procedures.
Cristina González‐Lara, Marina Piñar‐Lara, Esteban Obrero‐Gaitán, Héctor García‐López, Irene Cortés‐Pérez   +4 more
wiley   +1 more source

Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opioid receptor‐induced activation of c‐Jun N‐terminal kinase

, 2004
Opioid receptors are the therapeutic targets of narcotic analgesics. All three types of opioid receptors (μ, δ and κ) are prototypical Gi-coupled receptors with common signaling characteristics in their regulation of intracellular events.
Yung H. Wong, Angel Y. F. Kam, Anthony S. L. Chan, Kam, Angel Y.F., Wong, Yung H., Chan, Anthony S.L.   +5 more
core   +1 more source

κ-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells

, 2004
Opioid peptides exert diverse physiological functions through their cognate receptors. One subtype of the opioid receptors, κ-opioid receptor, is endogenously expressed in human monocytic THP-1 cells.
Kam, Angel Y.F., Wong, Yung H., Chan, Anthony S.L.   +2 more
core   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice

Journal of Integrative Neuroscience
Background: The overall pain experience results from the balance between the nociceptive pathway and the body’s endogenous modulation of nociception. The interaction of these systems reduces nociception.
Bárbara F. G. Queiroz, Walace C. P. Barra, Flávia C. S. Fonseca, Audrey L. Irie, Thiago R. L. Romero, Igor D. G. Duarte   +5 more
doaj   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

, 2016
Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4 ...
Michael A. Statnick (1816993), Steven J. Quimby (2138815), Vanessa N. Barth (1816987), Qing Shi (161182), Nuria Diaz (1817014), Alma Jimenez (2138806), David L. McKinzie (1947328), Concepcion Pedregal (2126134), Dana R. Benesh (2138809), Emily J. Canada (2138818), Charles H. Mitch (2138812), Steven D. Kahl (1816999), Karen S. Rash (1816972), Marta G. de la Torre (2138821)   +13 more
core   +1 more source

Opioids in cancer: The κ‑opioid receptor (Review). [PDF]

Mol Med Rep, 2022
Zhou Q, Zhang Z, Long S, Li W, Wang B, Liang N.   +5 more
europepmc   +1 more source