Results 121 to 130 of about 1,820,241 (196)
Personality and Mental Health, Volume 20, Issue 4, November 2026.ABSTRACT According to the functional ensemble of temperament (FET) model, individual differences in temperament arise from the balance of neurotransmitter systems also crucial for regulating circadian rhythms and sleep, suggesting a strong neurobiological link between temperament and sleep behavior.
Stefano Lasaponara +6 more
wiley +1 more source
Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. [PDF]
J Med Chem, 2023 Muratspahić E +10 more
europepmc +1 more source
Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects
European Journal of Neuroscience, Volume 64, Issue 9, November 2026.Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova +2 more
wiley +1 more source
, 2016 A structurally novel opioid κ receptor selective ligand has been identified. This compound, (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic, 10)
James B. Thomas (1324521) +11 more
core +1 more source
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. [PDF]
J Chem Inf Model, 2023 Salas-Estrada L +9 more
europepmc +1 more source
Pain Practice, Volume 26, Issue 8, November 2026.ABSTRACT Background Preoperative risk stratification to identify patients who develop acute refractory pain after lumbar spine surgery is a first step to prevent unfavorable outcomes. In this study, we aimed to develop and internally validate a clinically relevant, multidimensional prediction rule for preoperative risk assessment.
Ilse H. van de Wijgert +6 more
wiley +1 more source
Biased Opioid Receptor Ligands: Gain without Pain
, 2017 Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria.
Pandey, Shubhi +2 more
core +1 more source
Discovery of Novel Triazole-Based Opioid Receptor Antagonists
, 2016 We report the computer-aided design, chemical synthesis, and biological evaluation of a novel family of δ opioid receptor (DOR) antagonists containing a 1,2,4-triazole core structure that are structurally distinct from other known opioid receptor active ...
Youyi Peng (1828456) +6 more
core +1 more source
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. [PDF]
Protein Cell, 2023 Chen Y, Chen B, Wu T, Zhou F, Xu F.
europepmc +1 more source
, 2013 Primer sequences used for PCR to genotype μ/δ/κ-opioid receptor knockout (KO) and the corresponding genetic background wild type (WT) mice.
Yvonne Schmidt (488909) +2 more
core +1 more source