Results 91 to 100 of about 1,820,241 (196)

Secondary metabolites isolated from Pinus roxburghii and interpretation of their cannabinoid and opioid binding properties by virtual screening and in vitro studies

Saudi Pharmaceutical Journal, 2018
Pinus roxburghii is highly popular as a potent analgesic and anti-inflammatory agent; however its exact mechanism of action was not fully elucidated. We aimed to interpret the analgesic and anti-inflammatory activity of the total ethanol extract of Pinus
Rola M. Labib, Radhakrishnan Srivedavyasasri, Fadia S. Youssef, Samir A. Ross   +3 more
doaj   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, Volume 65, Issue 12, Page 2497-2508, December 2026.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]

, 2012
Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas, Schwarz, Wolfgang, Xu, Nanjie, Pu, Lu, Pei, Gang, Gu, Quanbao, Xia, Peng, Ren, Shuanglai   +7 more
core   +1 more source

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(pyrrolidin-1-yl)cyclohexyl]acetamide hydrochloride: (±)-U50,488H

IUCrData
The crystal structure of the methanol-solvated hydrochloride salt of the selective κ-opioid receptor agonist (±)-U50,488, namely, 1-{2-[2-(3,4-dichlorophenyl)-N-methylacetamido]cyclohexyl}pyrrolidin-1-ium chloride methanol monosolvate, C19H27Cl2N2O+·Cl ...
Yoshimi Ichimaru, Masaaki Kurihara
doaj   +1 more source

Opioid Use and Family Members' Experiences of Opioids in Paediatric Cancer Pain Management: An Integrative Review

Scandinavian Journal of Caring Sciences, Volume 40, Issue 4, December 2026.
ABSTRACT Aim To analyse the use of opioids in children with cancer and the experiences of their family members regarding opioids used in pain management to improve family nursing. Design An integrative review. Methods A systematic literature search was carried out in four databases (CINAHL, MEDLINE, PsycInfo and Scopus) in August 2023, and was ...
Noora Puusa, Eeva Harju, Maija‐Liisa Kalliomäki, Elina Haavisto   +3 more
wiley   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, Volume 143, Issue 41, November 5, 2026.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Activity of the δ-Opioid Receptor Is Partially Reduced, Whereas Activity of the κ-Receptor Is Maintained in Mice Lacking the μ-Receptor

, 1998
Previous pharmacological studies have indicated the possible existence of functional interactions between μ-, δ- and κ-opioid receptors in the CNS. We have investigated this issue using a genetic approach. Here we describe in vitro and in vivo functional
Roques, B. P., Valverde Granados, Olga, Maldonado, Rafael, 1961-, Kieffer, Bruno, Vonesch, J. L., Negri, L., B. P. Roques, Denavit-Saubié, M., Smadja, C., R. Maldonado, C. Severini, A. S. Foutz, Severini, C., E. Boudinot, B. L. Kieffer, L. Negri, Roques, Bernard P., O. Valverde, Matthes, H. W., Kieffer, Brigitte L., J.-L. Vonesch, Boudinot, E., Boudinot, Eliane, Maldonado, R., H. W. D. Matthes, Matthes, Hans W. D., M. Denavit-Saubié, Severini, Cintia, Valverde, O., Negri, Lucia, Foutz, A. S., C. Smadja, Kieffer, B.L., Vonesch, J-L.   +33 more
core   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Frontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony, Bincy Baby, Ranjit Vijayan, Ranjit Vijayan, Ranjit Vijayan   +4 more
doaj   +1 more source

Major Effect of Pyrrolic N-Benzylation in Norbinaltorphimine, the Selective κ-Opioid Receptor Antagonist

, 2016
Indolic N-benzylation of naltrindole reportedly extends the duration of δ-opioid receptor (DOR) antagonism. Similar modification of the κ-opioid receptor (KOR) antagonist norBNI (1a) and its 17,17‘-diNMe analogue (1d), a low potency μ-opioid receptor ...
Sanjay K. Srivastava (219838), Carl N. Miller (2690473), Stephen M. Husbands (1290513), John R. Traynor (1290504), Cédric Chauvignac (2690470), John W. Lewis (1290534)   +5 more
core   +1 more source