Results 101 to 110 of about 28,832 (208)

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator

Journal of Pharmacological Sciences, 2018
Oxytocin (OT) is a 9-amine neuropeptide that plays an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. OT has been reported to exert an analgesic effect in both humans and animals, and the results of certain animal ...
Yoshiyuki Meguro, Kanako Miyano, Shigeto Hirayama, Yuki Yoshida, Naoto Ishibashi, Takumi Ogino, Yuriko Fujii, Sei Manabe, Moeko Eto, Miki Nonaka, Hideaki Fujii, Yoichi Ueta, Minoru Narita, Naohiro Sata, Toshihiko Yada, Yasuhito Uezono   +15 more
doaj   +1 more source

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]

, 2017
INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya, Ding, Lili, Geisler, Kristie, Ji, Hong, Martin, Lisa J, Sadhasivam, Senthilkumar, Stubbeman, Bobbie L, Weirauch, Matthew T, Zhang, Xue   +8 more
core   +1 more source

Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno, Andressa Nunes Mouta, Larissa de Sant' Ana Alves, Kathryn Nóbrega Arcoverde, Herbert Reis Aragão, Jerson Marques Cavalcante, Valéria Veras de Paula   +6 more
wiley   +1 more source

Effects on Breathing of Agonists to μ-opioid or GABA\u3csub\u3eA\u3c/sub\u3e Receptors Dialyzed into the Ventral Respiratory Column of Awake and Sleeping Goats [PDF]

, 2017
Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC).
Burgraff, Nicholas J., Crumley, Emma, Forster, Hubert V., Hodges, Matthew R., Langer, Thomas M., III, Neumueller, Suzanne E., Pan, Lawrence, Talwar, Sawan   +7 more
core   +1 more source

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity [PDF]

, 2012
Background: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell ...
Beguin, Cecile Andree, Berry, Loren M, Carlezon, William A., Carroll, F Ivy, Cohen, Bruce Michael, Munro, Thomas A, Van't Veer, Ashlee Victoria, Zhao, Zhiyang   +7 more
core   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms [PDF]

, 2014
Background: Muntingia calabura (Elaecoparceae) is a medicinal plant traditionally used, particularly, by the Peruvian people to alleviate headache and cold, pain associated with gastric ulcers or to reduce the prostate gland swelling.
Abdul Kader, Arifah, Cheema, Manraj Singh, Mohd Sani, Mohd Hijaz, Salleh, Mohd Zaki, Teh, Lay Kek, Zakaria, Zainul Amiruddin   +5 more
core   +1 more source

Older Age Is Associated With Long‐Term Retention in Buprenorphine Treatment for Opioid Use Disorder

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Opioid use disorder (OUD) among older adults is a fast‐growing public health problem. However, little is known about treatment outcomes among older adults in office‐based buprenorphine programs. Thus, our objective was to examine how age is associated with buprenorphine treatment outcomes among adults with OUD who initiate ...
Justina L. Groeger, Tiffany Lu, Andrea Jakubowski, Chenshu Zhang, Yuting Deng, Hector Perez, Frank DiRenno, Benjamin M. Jadow, Benjamin T. Hayes, Shadi Nahvi, Chinazo O. Cunningham, Joanna L. Starrels   +11 more
wiley   +1 more source

The Influence of Gene Polymorphism OPRM1 118A/G on the Perception of Pain and Pharmacodynamics of Narcotic Analgesics

Общая реаниматология, 2014
The polymorphism of μ-opioid receptor is one of the most studied polymorphisms that affect the activity of narcotic analgesics. Despite that there are a large number of publications dealing with the problem, the obtained results are not being currently ...
V. M. Zhenilo, O. A. Makharin
doaj   +1 more source

Evaluation of buprenorphine as optimisation of postoperative analgesia in feral cats undergoing ovariohysterectomy under field conditions

Journal of Small Animal Practice, EarlyView.
Objectives The objective of this prospective, randomised, blinded, observational clinical study was to investigate the effect of subcutaneously administered buprenorphine on postoperative pain in female feral cats undergoing ovariohysterectomy as part of a trap‐neuter‐return programme.
V. Heitzmann, A. Diggelmann, E. Goldinger, A. Schiele   +3 more
wiley   +1 more source