Results 21 to 30 of about 19,726 (227)

Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics

Molecules, 2021
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use.
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet   +5 more
doaj   +1 more source

Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of μ-Opioid Receptors in Bone Cancer Pain Rats

Dose-Response, 2019
Backgrounds: This study compared analgesic effects and μ-opioid receptor expression levels during long-term intraperitoneal and intrathecal treatment in a bone cancer pain rat.
Wei Liu, Heqi Liu, Zongde Zhang, Jiapeng Huang   +3 more
doaj   +1 more source

Highly-selective µ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model

BMC Research Notes, 2020
Objectives Dopamine-replacement utilizing L-DOPA is still the mainstay treatment for Parkinson’s disease (PD), but often leads to development of L-DOPA-induced dyskinesia (LID), which can be as debilitating as the motor deficits.
Mitchell J. Bartlett, Lisa Y. So, Lajos Szabò, David P. Skinner, Kate L. Parent, Michael L. Heien, Todd W. Vanderah, Robin Polt, Scott J. Sherman, Torsten Falk   +9 more
doaj   +1 more source

Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

NeuroImage: Clinical, 2019
Objective: To evaluate, in vivo, the impact of ongoing chronic migraine (CM) attacks on the endogenous μ-opioid neurotransmission. Background: CM is associated with cognitive-emotional dysfunction. CM is commonly associated with frequent acute medication
Hassan Jassar, Thiago D. Nascimento, Niko Kaciroti, Marcos F. DosSantos, Theodora Danciu, Robert A. Koeppe, Yolanda R. Smith, Marcelo E. Bigal, Frank Porreca, Kenneth L. Casey, Jon-Kar Zubieta, Alexandre F. DaSilva   +11 more
doaj   +1 more source

A Chimeric Analysis of the Opioid Receptor Domains Critical for the Binding Selectivity of μ Opioid Ligands

Neurobiology of Disease, 1996
The μ opioid receptor plays a key role in mediating the physiological, pharmacological, and behavioral effects of endogenous opioids and of opiate drugs such as morphine and heroin.
Brendon Watson, Fan Meng, Huda Akil
doaj   +1 more source

Comparison of Five Benzodiazepine-Receptor Agonists on Buprenorphine-Induced µ-Opioid Receptor Regulation

Journal of Pharmacological Sciences, 2009
.: In this study, we compared the effects of five short-, medium-, or long-acting benzodiazepine-receptor agonists (BZDs) [alprazolam (APZ), clonazepam (CLZ), flunitrazepam (FLZ), loprazolam (LPZ), zolpidem (ZLP)], at two distinct doses, 0.2 and 2 mg/kg,
Géraldine Poisnel, Martine Dhilly, Reynald Le Boisselier, Louisa Barre, Danièle Debruyne   +4 more
doaj   +1 more source

The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia

Frontiers in Systems Neuroscience, 2022
Due to the prevalence of chronic pain worldwide, there is an urgent need to improve pain management strategies. While opioid drugs have long been used to treat chronic pain, their use is severely limited by adverse effects and abuse liability ...
Susan T. Lubejko, Robert D. Graham, Giulia Livrizzi, Robert Schaefer, Matthew R. Banghart, Meaghan C. Creed, Meaghan C. Creed, Meaghan C. Creed, Meaghan C. Creed   +8 more
doaj   +1 more source

Intrathecal morphine exacerbates paresis with increasing muscle tone of hindlimbs in rats with mild thoracic spinal cord injury but without damage of lumbar α-motoneurons.

PLoS ONE, 2022
Adverse effects of morphine on locomotor function after moderate to severe spinal cord injury (SCI) have been reported; however, the effects after mild SCI without damage of lumbar α-motoneurons have not been investigated.
Katsuhiro Kawakami, Satoshi Tanaka, Yuki Sugiyama, Noriaki Mochizuki, Mikito Kawamata   +4 more
doaj   +2 more sources

μ-opioid receptor system mediates reward processing in humans

Nature Communications, 2018
μ-opioid signalling has a known role in the response to various rewarding stimuli, including pleasant foods. Here, Nummenmaa et al. show using PET and fMRI that individual differences in brain μ-opioid receptor density predict the strength of the neural ...
Lauri Nummenmaa, Tiina Saanijoki, Lauri Tuominen, Jussi Hirvonen, Jetro J. Tuulari, Pirjo Nuutila, Kari Kalliokoski   +6 more
doaj   +1 more source

Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2-a]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action

Molecules, 2022
The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the final effect of analgesia.
Dominik Straszak, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Marcin Kołaczkowski, Aldona Pietrzak, Mansur Rahnama-Hezavah, Bartłomiej Drop, Dariusz Matosiuk   +8 more
doaj   +1 more source