Results 71 to 80 of about 109,441 (301)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

σ-phase precipitation in weld metal of austenitic stainless steels and its effect on properties

Hanjie xuebao
Low-temperature conditions necessitate high toughness in the welded joints of austenitic stainless steel structures. However, the impact toughness of the weld metal decreases significantly when using electrodes developed for SMAW under such conditions ...
Xuegang ZHANG, Xuchao GUO, Shuaijie JIAO, Meng WANG, Yan CHEN, Tingting SUN, Pengliang HU   +6 more
doaj   +1 more source

Connection between vibrational dynamics and topological order in simple glasses

, 2000
We compare vibrational dynamics in two structurally distinct, simple monatomic model glasses simulated by molecular dynamics: the Lennard-Jones glass with an fcc-related structure and a glass with predominantly icosahedral short-range order.
Dzugutov, M., Elliott, S. R., Simdyankin, S. I., Taraskin, S. N.   +3 more
core   +1 more source

Controlled self-assembly of periodic and aperiodic cluster crystals [PDF]

, 2014
Soft particles are known to overlap and form stable clusters that self-assemble into periodic crystalline phases with density-independent lattice constants.
Barkan, Kobi, Engel, Michael, Lifshitz, Ron   +2 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Study on σ Phase in Fe–Al–Cr Alloys

Metals, 2019
In this paper, a method of using the second phase to control the grain growth in Fe−Al−Cr alloys was proposed, in order to obtain better mechanical properties.
Jintao Wang, Shouping Liu, Xiaoyu Han
doaj   +1 more source

Influence of solid phase thermal conductivity on species separation rate in packed thermogravitational columns: A direct numerical simulation model [PDF]

, 2011
n this work, a direct numerical simulation model has been proposed to study the influence of porous matrix thermal properties on the separation rate in a model of packed thermogravitational column saturated by a binary mixture. The coupled flow, heat and
Davarzani, Hossein, Marcoux, Manuel
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Effect of Yttrium Addition on the Solidification Microstructure and Sigma Phase Precipitation Behavior of S32654 Super Austenitic Stainless Steel

Metals
This study focuses on S32654 super austenitic stainless steel (SASS) and systematically characterizes the morphology of the sigma (σ) phase and the segregation behavior of alloying elements in its as-cast microstructure.
Jun Xiao, Geng Tian, Di Wang, Shaoguang Yang, Kuo Cao, Jianhua Wei, Aimin Zhao   +6 more
doaj   +1 more source

Σ-Δ modulation analysis and optimization in fractional-N frequency synthesizer

Dianzi Jishu Yingyong, 2018
Analyzed the impaction of Σ-Δ modulation on Σ-Δ frequency synthesizer′s phase noise and spurs, and optimized Σ-Δ modulator to improve the performance of Σ-Δ frequency synthesizer.
Yang Jianming
doaj   +1 more source