Results 21 to 30 of about 45 (45)

Фармакогенетика аминогликозидной тугоухости

Качественная клиническая практика, 2018
Поводом для генетических исследований при аминогликозидной тугоухости явилось появление в литературе описания семейных случаев тугоухости, развившихся в результате применения аминогликозидных антибиотиков (АГ), вначале в Японии в 1957 году, а затем и в ...

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Половые различия в биотрансформации лекарственных средств: значение для проведения клинических исследований лекарственных средств

Фармакокинетика и Фармакодинамика, 2020
Долгое время клинические исследования лекарственных средств I и II фазы у женщин не проводились, что было связано с опасениями негативного воздействия на возможную беременность и плод.

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Pharmacogenetics of antipsychotic-induced metabolic disturbances: state-of-the-art

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
Antipsychotics are the main pharmaceutical agents in treatment of schizophrenia and other mental disorders. According to literature data up to 60% of patients with schizophrenia have antipsychotic-induced metabolic disturbances.
R. F. Nasyrova, N. A. Sivakova, D. V. Ivashchenko, D. N. Sosin, E. E. Ershov, K. A. Sosina, L. Sh. Akhmetova, O. V. Volikova, T. Z. Beybalayeva, N. G. Neznanov   +9 more
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Pharmacogenetic Warfarin Dosing Algorithm in the Russian Population

Acta Biomedica Scientifica, 2019
Background. To date, there are many pharmacogenetic algorithms for selecting the dose of warfarin. However, there is very little information about the predictive accuracy of the algorithms.
T. A. Bairova, A. Yu. Sambyalova, L. V. Rychkova, E. A. Novikova, F. I. Belyalov, D. S. Sargaeva, E. A. Shchedreeva, T. G. Ignatyeva, O. A. Ershova, V. G. Pustozerov, O. A. Kovaleva, I. V. Rasputina, I. A. Noskova, T. V. Batogova, O. V. Kuznetsova, O. Yu. Bogoslova, S. I. Kolesnikov   +16 more
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RETRACTED: Efficacy and safety of medicines: the value and opportunities of clinical pharmacology

Регуляторные исследования и экспертиза лекарственных средств, 2018
RETRACTED ARTICLEBrief description of the opportunities and benefits of applying the methodology of clinical pharmacology and personalized medicine, pharmacokinetics, and pharmacodynamics of medicines, as well as the possibilities of evaluation of ...
M. V. Zhuravleva, V. G. Kukes, A. B. Prokofiev, V. V. Arkhipov, Yu. V. Olefir, S. Yu. Serebrova, A. V. Sokolov, D. A. Sychev   +7 more
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APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY

Рациональная фармакотерапия в кардиологии, 2015
The clinical significance of the SLCO1B1 gene polymorphism (encoding an organic anion transport polipeptide) in the development of statin induced myopathy is considered.
D. A. Sychev, G. N. Shuev, A. B. Prokofiev   +2 more
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The importance of pharmacogenetic research for optimization of antihypertensive treatment

RUDN Journal of Medicine, 2012
As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding ...
O V Shevchenko, E N Bychkov, O M Posnenkova, P Ya Dovgalevsky, S I Bogoslovskaya, A A Svistunov   +5 more
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EVALUATION OF SENSITIVITY TO CLOPIDOGREL: THE CURRENT STATE OF THE PROBLEM

Атеротромбоз, 2015
The review deals with the laboratory assessment of clopidogrel effect in patients with CHD. The article presents the results of major studies that have demonstrated the relationship between the residual platelet reactivity level and drug pharmacogenetics
A. L. Komarov
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THE SIGNIFICANCE OF PHARMACOGENETIC CYP2C19 TESTING FOR PERSONALIZATION OF THE ANTIPLATELET THERAPY IN CARDIOLOGY PRACTICE

Рациональная фармакотерапия в кардиологии, 2015
The clinical significance  of CYP2C19 genetic polymorphism, associated with the violation of the formation of the active clopidogrel metabolite, for efficacy and safety of this drug in cardiology practice is discussed.
K. B. Mirzaev, D. A. Sychev, D. A. Andreev, A. B. Prokofiev   +3 more
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Clinical and genetic characteristics of treatment-resistant asthma

Медицинский совет, 2013
Therapy resistant asthma (TRA) is most difficult to treat and its course is least predictable. TRA remains least studied despite the fact that its many mechanisms have been detected.
V. I. Trofimov, G. A. Mironova
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