Results 21 to 30 of about 9,415 (168)
Journal of Diabetes, Volume 15, Issue 6, Page 519-531, June 2023., 2023 Highlights For distinguishing glucokinase maturity‐onset diabetes of the young (GCK‐MODY) from hepatocyte nuclear factor 1‐α MODY (HNF1A‐MODY), total triglycerides may help during the follow‐up period. In order to discriminate GCK‐MODY from MODY‐like type 2 diabetes, high‐sensitivity C‐reactive protein may be a suitable indicator in the early stage ...
Jing Liu +3 more
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Journal of Diabetes, Volume 15, Issue 5, Page 436-447, May 2023., 2023 Highlights To our knowledge, our study is the first to date to investigate the association between metabolically defined obesity and adverse outcomes in patients with chronic myeloid leukemia (CML). Metabolic abnormalities were associated with adverse outcomes in patients with CML, irrespective of obesity status.
Yingchun Dong +11 more
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Journal of Diabetes, Volume 15, Issue 4, Page 313-324, April 2023., 2023 Highlights Different microvascular phenotypes were detected by noninvasive optical coherence tomography angiography (OCTA) in metabolically healthy obesity and metabolic syndrome patients. Baseline blood pressure and insulin status may be key determinants for vascular benefit from bariatric surgery.
Yaying Chen +11 more
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Journal of Diabetes, Volume 15, Issue 2, Page 165-180, February 2023., 2023 Highlights For the first time, our study contributed a systematic evaluation of bile acid (BA) profiles in plasma, feces and liver tissue and gut microbiota changes triggered by fasting‐refeeding cycle in mice. Our work clearly demonstrated that overnight fasting leads to significant, but reversible changes in BA profiles and gut microbiota composition.
Yi Zhang +16 more
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Research Progress of Metabolomics Techniques Combined with Machine Learning Algorithm in Wound Age Estimation [PDF]
, 2023 Wound age estimation is the core content in the practice of forensic medicine. Accurate estimation of wound age is a scientific question that needs to be urgently solved by forensic scientists at home and abroad.
Xing-yu MA, Hao CHENG, Zhong-duo ZHANG, Ye-ming LI, Dong ZHAO
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NMR联用HILIC-UPLC-MS/MS测定TNBS诱导的结肠炎大鼠尿液和血浆代谢物变化
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的基于非靶标和靶标代谢组学技术，探讨三硝基苯磺酸（TNBS）诱导的结肠炎模型大鼠尿液以及血浆中内源性代谢物的变化。方法16只雄性SD大鼠随机分成对照组和模型组，每组8只，对模型组大鼠给予TNBS灌肠以建立实验性大鼠结肠炎模型。利用核磁共振氢谱（1H NMR）检测两组大鼠尿液代谢物，同时联用HILIC模式超高效液相色谱串联三重四级杆质谱（HILIC-UPLC-MS/MS）测定以上大鼠尿液以及血浆中氨基酸水平，并通过多元变量统计方法对代谢组学数据进行分析。结果同对照组相比，1H ...
刘雯 +7 more
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宏基因组联合UPLC-Q-TOF-MS/MS探讨地塞米松对大鼠肺炎的作用机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的基于多组学技术，探讨地塞米松（Dex）能否通过调节肠道菌群及代谢物治疗肺炎。方法将18只Sprague-Dawley大鼠随机均分为对照（Control）组、模型（Model）组和地塞米松（Dex）组，每组6只，除Control组外，余下两组持续使用4 mg/kg的脂多糖（LPS）腹腔注射7 d建立大鼠肺炎模型。然后Dex组给予2 mg/kg的Dex灌胃治疗12 d，余下两组均连续灌胃等量的无菌PBS缓冲液12 d。第19 d时收集大鼠的肺组织、血浆、粪便和肠道内容物。苏木精-伊红（H&E ...
李四菊 +5 more
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, 2020 Plant phenomics is under rapid development in recent years, a research field that is progressing towards integration, scalability, multi-perceptivity and high-throughput analysis.
Guohui, Ding +6 more
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代谢组学在代谢性脑血管病中的应用研究 Application of Metabolomics in Cerebro-Metabolic Disease
Zhongguo cuzhong zazhi脑血管病是全球范围内导致人类死亡和残疾的主要原因，其中很高比例与代谢紊乱相关。代谢性脑血管病是指由传统代谢危险因素和残余代谢危险因素导致的脑血管损害，以血管结构受损及功能障碍为主要病理生理学表现，干预代谢危险因素可有效改善预后的一种临床综合征。代谢组学是采用高通量组学技术对所有代谢物进行鉴定和定量的手段，是未来研究代谢性脑血管病的重要抓手。本文总结了代谢组学、脂质组学在代谢性心脑血管疾病方面的研究，旨在为代谢性脑血管病的代谢组学研究开展及其临床防治提供参考。 Abstract ...
钟文华1，薛婧2，许杰1，2 ( ZHONG Wenhua1, XUE Jing2, XU Jie1,2 )
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Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的比较食管鳞癌患者和健康志愿者的血清代谢谱，寻找食管鳞癌特有的代谢标志物。方法选择一组明确诊断的食管鳞癌患者作为实验组、一组健康志愿者作为对照组，以液相色谱-质谱法（LC-MS）检测其血清轮廓代谢谱，通过单变量分析和多变量（主成分分析及偏最小二乘回归分析法等）比较两组代谢谱并寻找差异性代谢物，通过代谢物质通路的富集分析探讨其可能异常生物学过程。结果入组食管鳞癌患者20例为实验组，健康对照20例为对照组，变异倍数分析和T检验等单因素分析结果得出21种差异性代谢物（P<0.05）；选择单变量分析P ...
黄伟钊 +5 more
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