Results 31 to 40 of about 4,016,779 (195)
Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023 Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 11, Page 968-977, November 2023., 2023 Highlights Among 301 studies, diabetes mellitus was the most studied cardiometabolic risk factor. In the network meta‐analysis, cerebrovascular disease had the highest impact (relative risk [RR] 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors.
Alina Binbin Li +9 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 11, Page 987-993, November 2023., 2023 Highlights We used data from the genome‐wide association studies database and two‐sample mendelian randomization method, we found that genetic evidence supporting that knee osteoarthritis is a potential risk factor for type 2 diabetes. Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Xing Xing +3 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 10, Page 900-910, October 2023., 2023 Highlights Mild acquired impaired thyroid hormone sensitivity was widespread among the general populations. Reduced thyroid hormone sensitivity was related with metabolic syndrome and its components. Impaired thyroid hormone sensitivity might affect the distribution of adipose tissue and muscle.
Fang Lv +6 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023 Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
wiley +1 more source
[Analysis of the relationship between neonatal birth weight and meconium metabolites based on birth cohort metabolomics]. [PDF]
Se Pu新生儿出生体重是反映新生儿在宫内生长和发育情况的重要指标,其对儿童发育及成人健康状况评价具有重要的意义。胎便是新生儿在母体分娩后排出的最初粪便,被认为是研究母婴健康状况的理想生物样本。本研究依托孝感市妇幼保健院建立的出生队列,采用基于液相色谱-高分辨质谱的非靶向代谢组学技术,采集了484例新生儿胎便的代谢组数据,筛选出不同出生体重组间的差异代谢物,并探究了相关分子机理。在该出生队列中,低出生体重儿(4000 g)的发病率分别为3.3%和7.2%,与全国平均水平基本相当。正交偏最小二乘判别分析结果显示 ...
Chen YJ, Lu ZH, Liang SJ, Zhang J.
europepmc +2 more sources
[Non-targeted Metabolomics-based Exploration of Radiation-induced Metabolic Alterations in Mouse Lung Epithelial Cells]. [PDF]
Zhongguo Fei Ai Za Zhi背景与目的 代谢变化是放射性肺炎的重要特征之一。放疗作为胸部肿瘤治疗的常规手段，在有效杀伤肿瘤细胞的同时也会引发局部炎症和纤维化等不良反应，进而导致治疗效果受限，严重影响患者生活质量。因此，深入探讨放疗引起的代谢改变具有重要意义。本研究旨在探究X射线辐射对小鼠肺上皮细胞系（murine lung epithelial-12, MLE12）代谢的影响。 方法 于体外环境下培养MLE12细胞系，并将其随机分为辐射组（radiation group，IR组）与对照组（control group，NC组 ...
Fan H, Ge X, Zhou X, Li Y, Liu Q, Hu Y.
europepmc +2 more sources
Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制
Journal of Diabetes, Volume 15, Issue 9, Page 736-752, September 2023., 2023 Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin +6 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 8, Page 640-648, August 2023., 2023 Highlights In Chinese postmenopausal women with type 2 diabetes mellitus, serum follicle‐stimulating hormone levels were negatively and independently associated with the prevalence of nonalcoholic fatty liver disease. Metabolic conditions, including overweight/obesity, central obesity, hyperuricemia, hypertension, and dyslipidemia did not interact with
Shengjie Ge +10 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 6, Page 519-531, June 2023., 2023 Highlights For distinguishing glucokinase maturity‐onset diabetes of the young (GCK‐MODY) from hepatocyte nuclear factor 1‐α MODY (HNF1A‐MODY), total triglycerides may help during the follow‐up period. In order to discriminate GCK‐MODY from MODY‐like type 2 diabetes, high‐sensitivity C‐reactive protein may be a suitable indicator in the early stage ...
Jing Liu +3 more
wiley +1 more source